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Mallinckrodt
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Generated: December 16, 2018

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CLINICAL TRIALS PROFILE FOR CHOLINE C-11

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Clinical Trials for Choline C-11

Trial ID Title Status Sponsor Phase Summary
NCT00003410 Motexafin Gadolinium With MRI-Guided Surgery in Treating Patients With High-Grade Gliomas Completed National Cancer Institute (NCI) Phase 1 RATIONALE: New imaging procedures such as the use of gadolinium texaphyrin with MRI may improve the ability to detect the extent of gliomas. PURPOSE: Phase I trial to study the effectiveness of gadolinium texaphyrin used with MRI-guided surgery in treating patients with high-grade glioma.
NCT00003410 Motexafin Gadolinium With MRI-Guided Surgery in Treating Patients With High-Grade Gliomas Completed Jonsson Comprehensive Cancer Center Phase 1 RATIONALE: New imaging procedures such as the use of gadolinium texaphyrin with MRI may improve the ability to detect the extent of gliomas. PURPOSE: Phase I trial to study the effectiveness of gadolinium texaphyrin used with MRI-guided surgery in treating patients with high-grade glioma.
NCT00004697 Randomized Study of the Use of Intravenous Choline Supplementation in Long Term Total Parenteral Nutrition Completed University of Texas N/A OBJECTIVES: I. Determine whether intravenous choline supplementation will reverse the hepatic steatosis and improve liver function in patients who receive long term total parenteral nutrition.
NCT00006061 Study of Phosphatidylcholine in a Patient With Methionine Adenosyltransferase Deficiency Completed UNC Lineberger Comprehensive Cancer Center N/A OBJECTIVES: I. Determine whether plasma choline and breast milk choline levels are low at fasting in a patient with methionine adenosyltransferase deficiency, and if the choline levels are low, determine whether choline levels respond to dietary supplementation with phosphatidylcholine. II. Determine whether this patient has a fatty liver by magnetic resonance spectroscopy.
NCT00006061 Study of Phosphatidylcholine in a Patient With Methionine Adenosyltransferase Deficiency Completed National Center for Research Resources (NCRR) N/A OBJECTIVES: I. Determine whether plasma choline and breast milk choline levels are low at fasting in a patient with methionine adenosyltransferase deficiency, and if the choline levels are low, determine whether choline levels respond to dietary supplementation with phosphatidylcholine. II. Determine whether this patient has a fatty liver by magnetic resonance spectroscopy.
NCT00031135 Total Parenteral Nutrition-Associated Liver Disease Terminated Northwestern University Phase 2 This is a study to determine whether choline, when added to total parenteral nutrition (TPN), can help prevent the development of hepatic steatosis, a liver disease, in patients on TPN.
NCT00069550 Independent Studies of Dextromethorphan and of Donepezil Hydrochloride for Rett Syndrome Unknown status Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Phase 3 Rett syndrome (RTT) is a disorder in which the nervous system does not develop properly. RTT generally affects girls, but there are some boys who have been diagnosed with RTT. Symptoms of RTT include small brain size, poor language skills, repetitive hand movements, and seizures. This study will evaluate the effectiveness of two drugs in treating the symptoms of RTT.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Choline C-11

Condition Name

Condition Name for Choline C-11
Intervention Trials
Prostate Cancer 15
Hypertriglyceridemia 5
Alzheimer's Disease 5
Dyslipidemia 4
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Condition MeSH

Condition MeSH for Choline C-11
Intervention Trials
Prostatic Neoplasms 20
Alzheimer Disease 6
Syndrome 5
Hypertriglyceridemia 5
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Clinical Trial Locations for Choline C-11

Trials by Country

Trials by Country for Choline C-11
Location Trials
United States 109
Spain 9
Korea, Republic of 8
Italy 6
France 6
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Trials by US State

Trials by US State for Choline C-11
Location Trials
California 14
Ohio 7
Illinois 7
New Jersey 6
Texas 6
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Clinical Trial Progress for Choline C-11

Clinical Trial Phase

Clinical Trial Phase for Choline C-11
Clinical Trial Phase Trials
Phase 4 21
Phase 3 23
Phase 2/Phase 3 1
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Clinical Trial Status

Clinical Trial Status for Choline C-11
Clinical Trial Phase Trials
Completed 44
Recruiting 31
Terminated 13
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Clinical Trial Sponsors for Choline C-11

Sponsor Name

Sponsor Name for Choline C-11
Sponsor Trials
National Cancer Institute (NCI) 14
Essentialis, Inc. 8
National Institutes of Health (NIH) 5
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Sponsor Type

Sponsor Type for Choline C-11
Sponsor Trials
Other 123
Industry 36
NIH 27
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Serving hundreds of leading biopharmaceutical companies globally:

Merck
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Baxter
Covington
Dow
QuintilesIMS
Chinese Patent Office
Colorcon
US Army

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