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Generated: December 16, 2018

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CLINICAL TRIALS PROFILE FOR CHLORAPREP ONE-STEP SEPP

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Clinical Trials for Chloraprep One-step Sepp

Trial ID Title Status Sponsor Phase Summary
NCT00290290 Efficacy Study of Antiseptic Preoperative Scrubs in Prevention of Postoperative Infections Completed Medical College of Wisconsin Phase 3 Most cases of infection of clean-contaminated wounds (wounds without gross spillage of organisms from the gastrointestinal tract) are thought to originate from the skin. Therefore, it is conceivable that application of an optimal antiseptic agent can reduce the rate of surgical wound infections. This trial is to compare the impact of disinfecting the skin with Chloraprep (2%chlorhexidine and 70% isopropyl alcohol) vs. Betadine on the rates of infection of clean-contaminated surgical wounds. The study will also assess the occurrence of adverse effects on the skin from either antiseptic agent and the cost-savings associated with the use of Chloraprep vs Betadine.
NCT00290290 Efficacy Study of Antiseptic Preoperative Scrubs in Prevention of Postoperative Infections Completed Michael Debakey Veterans Affairs Medical Center Phase 3 Most cases of infection of clean-contaminated wounds (wounds without gross spillage of organisms from the gastrointestinal tract) are thought to originate from the skin. Therefore, it is conceivable that application of an optimal antiseptic agent can reduce the rate of surgical wound infections. This trial is to compare the impact of disinfecting the skin with Chloraprep (2%chlorhexidine and 70% isopropyl alcohol) vs. Betadine on the rates of infection of clean-contaminated surgical wounds. The study will also assess the occurrence of adverse effects on the skin from either antiseptic agent and the cost-savings associated with the use of Chloraprep vs Betadine.
NCT00290290 Efficacy Study of Antiseptic Preoperative Scrubs in Prevention of Postoperative Infections Completed VA Office of Research and Development Phase 3 Most cases of infection of clean-contaminated wounds (wounds without gross spillage of organisms from the gastrointestinal tract) are thought to originate from the skin. Therefore, it is conceivable that application of an optimal antiseptic agent can reduce the rate of surgical wound infections. This trial is to compare the impact of disinfecting the skin with Chloraprep (2%chlorhexidine and 70% isopropyl alcohol) vs. Betadine on the rates of infection of clean-contaminated surgical wounds. The study will also assess the occurrence of adverse effects on the skin from either antiseptic agent and the cost-savings associated with the use of Chloraprep vs Betadine.
NCT00290290 Efficacy Study of Antiseptic Preoperative Scrubs in Prevention of Postoperative Infections Completed Baylor College of Medicine Phase 3 Most cases of infection of clean-contaminated wounds (wounds without gross spillage of organisms from the gastrointestinal tract) are thought to originate from the skin. Therefore, it is conceivable that application of an optimal antiseptic agent can reduce the rate of surgical wound infections. This trial is to compare the impact of disinfecting the skin with Chloraprep (2%chlorhexidine and 70% isopropyl alcohol) vs. Betadine on the rates of infection of clean-contaminated surgical wounds. The study will also assess the occurrence of adverse effects on the skin from either antiseptic agent and the cost-savings associated with the use of Chloraprep vs Betadine.
NCT00739583 Visibility of Site Marking for Surgical Time Out With Two Different Skin Preparation Solutions Completed Johns Hopkins University Phase 4 Skin preparation solutions are used to clean the skin of the patient before surgery to decrease the rate of infection. This is particularly important for hip replacement to reduce the risk of prosthetic joint infection. The use of a mark on the skin for site identification has become the standard of care to decrease wrong site surgery. The Joint Commission has mandated site identification as part of the surgical "time-out". This procedure is also mandated by hospital policy. Preliminary work on cadaveric skin shows that the type of skin preparation can erase the mark used for surgical site identification. Erasure of the mark presents the surgeon with difficulty in performing the site identification. Any error or lack of visualization of the site marking could lead to catastrophic wrong site surgery. The investigators hypothesis is that chlorhexidine based skin preparation solutions erase site marking in comparison to iodine based skin preparation solutions. The investigators intend to prospectively study twenty patients undergoing total hip arthroplasty. Patients will be randomized to either a chlorhexidine based or an iodine based skin preparation solution. These solutions are both the current gold standard of clinical care. No differences have been shown in infection rates for total hip arthroplasty between these solutions. The site marking will be performed by the same surgeon in a standardized manner. The site marking will include the surgeon's three initials as per usual routine. Underneath the initials three random initials will be placed with a horizontal line drawn underneath. The preparation of the skin will be performed according to the manufacturer's specifications. Digital photographs will be taken of the skin marking after skin preparation. Photographs of the three random initials will be de-identified and placed in a "Powerpoint" presentation form. Ten orthopaedic surgeons will then read the site markings to identify the random initials and to tell whether the mark looks appropriate to perform a surgical timeout. The horizontal line will be digitally analyzed using Adobe Photoshop to quantitatively measure blackness of the mark.
NCT00799812 Test for Preoperative Skin Preparations Completed CareFusion Phase 1/Phase 2 Compare 2 application techniques of ChloraPrep Swabstick--3 swabsticks at once versus 3 swabsticks used one-at-a-time. Hibiclens applied according to the manufacturer's directions. Sterile swabsticks (wetted with sterile water) applied using the same method as the ChloraPrep Swabstick.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Chloraprep One-step Sepp

Condition Name

Condition Name for Chloraprep One-step Sepp
Intervention Trials
Surgical Site Infection 8
Antimicrobial Effectiveness 2
Surgical Skin Preparation 2
Infection 2
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Condition MeSH

Condition MeSH for Chloraprep One-step Sepp
Intervention Trials
Surgical Wound Infection 9
Infection 4
Communicable Diseases 4
Bacteremia 2
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Clinical Trial Locations for Chloraprep One-step Sepp

Trials by Country

Trials by Country for Chloraprep One-step Sepp
Location Trials
United States 26
Canada 2
United Kingdom 1
Italy 1
Thailand 1
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Trials by US State

Trials by US State for Chloraprep One-step Sepp
Location Trials
Virginia 7
Montana 5
Pennsylvania 2
Maryland 2
Massachusetts 2
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Clinical Trial Progress for Chloraprep One-step Sepp

Clinical Trial Phase

Clinical Trial Phase for Chloraprep One-step Sepp
Clinical Trial Phase Trials
Phase 4 11
Phase 3 8
Phase 2 4
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Clinical Trial Status

Clinical Trial Status for Chloraprep One-step Sepp
Clinical Trial Phase Trials
Completed 15
Recruiting 7
Terminated 2
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Clinical Trial Sponsors for Chloraprep One-step Sepp

Sponsor Name

Sponsor Name for Chloraprep One-step Sepp
Sponsor Trials
Zurex Pharma, Inc. 7
3M 4
CareFusion 3
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Sponsor Type

Sponsor Type for Chloraprep One-step Sepp
Sponsor Trials
Other 18
Industry 17
U.S. Fed 2
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