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Generated: December 11, 2018

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CLINICAL TRIALS PROFILE FOR CHILDREN'S IBUPROFEN

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Clinical Trials for Children's Ibuprofen

Trial ID Title Status Sponsor Phase Summary
NCT00115336 Ketorolac Versus Ibuprofen to Treat Painful Episodes of Sickle Cell Disease Terminated National Heart, Lung, and Blood Institute (NHLBI) Phase 4 The purpose of this study is to compare ketorolac, a potent, non-steroidal anti-inflammatory drug (NSAID), with ibuprofen, a commonly used NSAID, for the treatment of the painful crisis of sickle cell disease (SCD).
NCT00115336 Ketorolac Versus Ibuprofen to Treat Painful Episodes of Sickle Cell Disease Terminated University of Texas Southwestern Medical Center Phase 4 The purpose of this study is to compare ketorolac, a potent, non-steroidal anti-inflammatory drug (NSAID), with ibuprofen, a commonly used NSAID, for the treatment of the painful crisis of sickle cell disease (SCD).
NCT00121563 Evaluation of a TNF-Alpha Modulator for Clinical and Molecular Indicators of Analgesic Effect Completed National Institute of Nursing Research (NINR) Phase 2 This study will evaluate the role of thalidomide, a tumor necrosis factor (TNF)-alpha modulator, on severe inflammation and relief of pain following extraction of wisdom teeth. TNFs are substances that affect the pathways of pain. This study involves an experimental group in which patients will be given thalidomide or a placebo (an inactive substance); a negative control group receiving the medication diazepam or a placebo; and a positive control group receiving diazepam or ibuprofen. Patients who are males ages 16 to 35, who are not allergic to aspirin or other nonsteroidal anti-inflammatory drugs (known as NSAIDs), sulfites, or certain anesthetics, and who in good health may be eligible for this study. Females are not eligible, owing to the risks that thalidomide presents to unborn children. To minimize the risk of fetal malformations, male patients who participate must use a condom during sexual intercourse for 4 weeks following the study and must not donate blood for 4 weeks. The medications used in the study will be given 1 hour before surgery. Then after the wisdom teeth are removed, a small piece of tubing will be placed into both sides of the patient's mouth where the teeth were removed. Every 20 minutes, for the next 6 hours, the researchers will collect inflammatory fluid from the tubing, to measure for changes in anti-inflammatory action. If they request pain relievers, patients will receive the medication ketorolac (Toradol), used for short-term treatment of moderately severe acute pain. Side effects of thalidomide include fatigue, dizziness, and rash. The use of ibuprofen and ketorolac may include the risk of gastrointestinal ulcers and bleeding. Diazepam can cause involuntary muscle movements and drowsiness, as well as dizziness lasting for up to 24 hours after it has been used as sedation. Patients will be instructed not to try to walk alone or to try to drive a vehicle during that period. Other risks related to participation in this study include those usually experienced with removal of wisdom teeth-that is, pain and swelling, bruising from insertion of the sedative into a vein (if needed), possible infection at the extraction site, prolonged bleeding, and numbness. Benefits from participating are having wisdom teeth removed at no cost as well as close monitoring before and after surgery. Results from the study may help people in the future by improving the management of pain following surgery.
NCT00167713 Treatment of Fever Due to Malaria With Ibuprofen Completed Albert Schweitzer Hospital Phase 4 Drugs to treat fever are widely used in children with fever. But there is a controversy about the benefit of reducing fever in children with malaria. Ibuprofen is often used to treat malarial fever. This study evaluates the capacity of ibuprofen to reduce fever in malaria. The effect of ibuprofen on fever compared to only mechanical measures is investigated in children with malaria.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Children's Ibuprofen

Condition Name

Condition Name for Children's Ibuprofen
Intervention Trials
Fever 9
Pain 7
Pain, Postoperative 4
Healthy 3
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Condition MeSH

Condition MeSH for Children's Ibuprofen
Intervention Trials
Pain, Postoperative 11
Fever 7
Fractures, Bone 5
Tonsillitis 3
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Clinical Trial Locations for Children's Ibuprofen

Trials by Country

Trials by Country for Children's Ibuprofen
Location Trials
United States 43
Canada 12
Israel 5
France 3
Egypt 3
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Trials by US State

Trials by US State for Children's Ibuprofen
Location Trials
Texas 6
North Carolina 3
Washington 3
California 3
Pennsylvania 3
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Clinical Trial Progress for Children's Ibuprofen

Clinical Trial Phase

Clinical Trial Phase for Children's Ibuprofen
Clinical Trial Phase Trials
Phase 4 20
Phase 3 6
Phase 2/Phase 3 2
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Clinical Trial Status

Clinical Trial Status for Children's Ibuprofen
Clinical Trial Phase Trials
Completed 24
Not yet recruiting 17
Recruiting 13
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Clinical Trial Sponsors for Children's Ibuprofen

Sponsor Name

Sponsor Name for Children's Ibuprofen
Sponsor Trials
St. Justine's Hospital 4
Lawson Health Research Institute 4
Assaf-Harofeh Medical Center 3
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Sponsor Type

Sponsor Type for Children's Ibuprofen
Sponsor Trials
Other 81
U.S. Fed 11
Industry 10
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Serving hundreds of leading biopharmaceutical companies globally:

Cerilliant
Accenture
Johnson and Johnson
Daiichi Sankyo
Covington
McKesson
Cantor Fitzgerald
Argus Health
Moodys

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