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Last Updated: February 7, 2023

CLINICAL TRIALS PROFILE FOR CARNITOR


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All Clinical Trials for Carnitor

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00227266 ↗ Valproic Acid and Carnitine in Patients With Spinal Muscular Atrophy Completed Abbott Phase 2 2005-09-01 This is a multi-center trial to assess safety and efficacy of a combined regimen of oral valproic acid (VPA) and carnitine in patients with Spinal Muscular Atrophy (SMA) 2 to 17 years of age. Cohort 1 is a double-blind placebo-controlled randomized intention to treat protocol for SMA "sitters" 2 - 8 years of age. Cohort 2 is an open label protocol for SMA "standers and walkers" 3 - 17 years of age to explore responsiveness of efficacy outcomes. Outcome measures will include blood chemistries, functional testing, pulmonary function testing, electrophysiological evaluations, PedsQL quality of life assessment, quantitative assessments of survival motor neuron (SMN) mRNA from blood samples, growth and vital sign parameters. Six centers will enroll a total of 90 patients.
NCT00227266 ↗ Valproic Acid and Carnitine in Patients With Spinal Muscular Atrophy Completed Families of Spinal Muscular Atrophy Phase 2 2005-09-01 This is a multi-center trial to assess safety and efficacy of a combined regimen of oral valproic acid (VPA) and carnitine in patients with Spinal Muscular Atrophy (SMA) 2 to 17 years of age. Cohort 1 is a double-blind placebo-controlled randomized intention to treat protocol for SMA "sitters" 2 - 8 years of age. Cohort 2 is an open label protocol for SMA "standers and walkers" 3 - 17 years of age to explore responsiveness of efficacy outcomes. Outcome measures will include blood chemistries, functional testing, pulmonary function testing, electrophysiological evaluations, PedsQL quality of life assessment, quantitative assessments of survival motor neuron (SMN) mRNA from blood samples, growth and vital sign parameters. Six centers will enroll a total of 90 patients.
NCT00227266 ↗ Valproic Acid and Carnitine in Patients With Spinal Muscular Atrophy Completed Leadiant Biosciences, Inc. Phase 2 2005-09-01 This is a multi-center trial to assess safety and efficacy of a combined regimen of oral valproic acid (VPA) and carnitine in patients with Spinal Muscular Atrophy (SMA) 2 to 17 years of age. Cohort 1 is a double-blind placebo-controlled randomized intention to treat protocol for SMA "sitters" 2 - 8 years of age. Cohort 2 is an open label protocol for SMA "standers and walkers" 3 - 17 years of age to explore responsiveness of efficacy outcomes. Outcome measures will include blood chemistries, functional testing, pulmonary function testing, electrophysiological evaluations, PedsQL quality of life assessment, quantitative assessments of survival motor neuron (SMN) mRNA from blood samples, growth and vital sign parameters. Six centers will enroll a total of 90 patients.
NCT00227266 ↗ Valproic Acid and Carnitine in Patients With Spinal Muscular Atrophy Completed Sigma Tau Pharmaceuticals, Inc. Phase 2 2005-09-01 This is a multi-center trial to assess safety and efficacy of a combined regimen of oral valproic acid (VPA) and carnitine in patients with Spinal Muscular Atrophy (SMA) 2 to 17 years of age. Cohort 1 is a double-blind placebo-controlled randomized intention to treat protocol for SMA "sitters" 2 - 8 years of age. Cohort 2 is an open label protocol for SMA "standers and walkers" 3 - 17 years of age to explore responsiveness of efficacy outcomes. Outcome measures will include blood chemistries, functional testing, pulmonary function testing, electrophysiological evaluations, PedsQL quality of life assessment, quantitative assessments of survival motor neuron (SMN) mRNA from blood samples, growth and vital sign parameters. Six centers will enroll a total of 90 patients.
NCT00227266 ↗ Valproic Acid and Carnitine in Patients With Spinal Muscular Atrophy Completed University of Utah Phase 2 2005-09-01 This is a multi-center trial to assess safety and efficacy of a combined regimen of oral valproic acid (VPA) and carnitine in patients with Spinal Muscular Atrophy (SMA) 2 to 17 years of age. Cohort 1 is a double-blind placebo-controlled randomized intention to treat protocol for SMA "sitters" 2 - 8 years of age. Cohort 2 is an open label protocol for SMA "standers and walkers" 3 - 17 years of age to explore responsiveness of efficacy outcomes. Outcome measures will include blood chemistries, functional testing, pulmonary function testing, electrophysiological evaluations, PedsQL quality of life assessment, quantitative assessments of survival motor neuron (SMN) mRNA from blood samples, growth and vital sign parameters. Six centers will enroll a total of 90 patients.
NCT00481013 ↗ Valproic Acid in Ambulant Adults With Spinal Muscular Atrophy Completed Abbott Phase 2 2007-07-01 The primary objective of this proposal is to determine whether oral VPA is effective in treating SMA in adult patients.
NCT00481013 ↗ Valproic Acid in Ambulant Adults With Spinal Muscular Atrophy Completed Families of Spinal Muscular Atrophy Phase 2 2007-07-01 The primary objective of this proposal is to determine whether oral VPA is effective in treating SMA in adult patients.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Carnitor

Condition Name

Condition Name for Carnitor
Intervention Trials
Spinal Muscular Atrophy 2
Carnitine Deficiency 2
Mixed Phenotype Acute Leukemia 1
Neurodevelopmental Disorder 1
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Condition MeSH

Condition MeSH for Carnitor
Intervention Trials
Leukemia 2
Muscular Atrophy, Spinal 2
Muscular Atrophy 2
Atrophy 2
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Clinical Trial Locations for Carnitor

Trials by Country

Trials by Country for Carnitor
Location Trials
United States 8
Canada 2
Netherlands 1
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Trials by US State

Trials by US State for Carnitor
Location Trials
Ohio 2
Texas 1
New York 1
Wisconsin 1
Utah 1
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Clinical Trial Progress for Carnitor

Clinical Trial Phase

Clinical Trial Phase for Carnitor
Clinical Trial Phase Trials
Phase 4 1
Phase 3 1
Phase 2/Phase 3 1
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Clinical Trial Status

Clinical Trial Status for Carnitor
Clinical Trial Phase Trials
Completed 2
Recruiting 1
Active, not recruiting 1
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Clinical Trial Sponsors for Carnitor

Sponsor Name

Sponsor Name for Carnitor
Sponsor Trials
Abbott 2
Families of Spinal Muscular Atrophy 2
University of Utah 2
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Sponsor Type

Sponsor Type for Carnitor
Sponsor Trials
Other 11
Industry 4
NIH 1
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