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CLINICAL TRIALS PROFILE FOR CANAGLIFLOZIN

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Clinical Trials for Canagliflozin

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT00642278	An Efficacy, Safety, and Tolerability Study of Canagliflozin (JNJ-28431754) in Patients With Type 2 Diabetes	Completed	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	Phase 2	2008-04-01	The purpose of this study is to evaluate the effectiveness, safety, and tolerability of JNJ-28431754 compared with placebo in patients with type 2 diabetes.
NCT00650806	A Study of the Safety and Effectiveness of Canagliflozin (JNJ-28431754) in Promoting Weight Loss in Overweight and Obese Patients Who do Not Have Diabetes	Completed	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	Phase 2	2008-05-01	The purpose of this study is to test the safety and effectiveness of JNJ-28431754 in promoting weight loss in patients who are overweight or obese and who do not have diabetes.
NCT00963768	A Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Study of JNJ-28431754 in Patients With Type 2 Diabetes Mellitus	Completed	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	Phase 1	2007-06-01	The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (ie, blood levels of JNJ-28431754) and pharmacodynamics (ie, urine and blood levels of glucose) of JNJ-28431754 compared to placebo in patients with Type 2 diabetes mellitus.
NCT00968812	CANagliflozin Treatment And Trial Analysis-Sulfonylurea (CANTATA-SU) SGLT2 Add-on to Metformin Versus Glimepiride	Completed	Janssen Research & Development, LLC	Phase 3	2009-09-01	The purpose of this study is to demonstrate the efficacy, safety, and tolerability of canagliflozin (JNJ-28431754) compared with glimepiride in patients with type 2 diabetes mellitus with inadequate control despite treatment with metformin.

Clinical Trial Conditions for Canagliflozin

Condition Name

Condition Name for Canagliflozin
Intervention	Trials
Healthy	40
Diabetes Mellitus, Type 2	33
Type 2 Diabetes Mellitus	12
Healthy Volunteers	4

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Condition MeSH

Condition MeSH for Canagliflozin
Intervention	Trials
Diabetes Mellitus	53
Diabetes Mellitus, Type 2	51
Overweight	4
Heart Failure	3

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Clinical Trial Locations for Canagliflozin

Trials by Country

Trials by Country for Canagliflozin
Location	Trials
United States	506
Canada	60
Mexico	17
India	16
Germany	14

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Trials by US State

Trials by US State for Canagliflozin
Location	Trials
Florida	28
California	27
Texas	24
Arizona	24
Georgia	17

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Clinical Trial Progress for Canagliflozin

Clinical Trial Phase

Clinical Trial Phase for Canagliflozin
Clinical Trial Phase	Trials
Phase 4	21
Phase 3	18
Phase 2	9

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Clinical Trial Status

Clinical Trial Status for Canagliflozin
Clinical Trial Phase	Trials
Completed	73
Recruiting	18
Not yet recruiting	11

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Clinical Trial Sponsors for Canagliflozin

Sponsor Name

Sponsor Name for Canagliflozin
Sponsor	Trials
Janssen Research & Development, LLC	40
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	31
Janssen Scientific Affairs, LLC	8

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Sponsor Type

Sponsor Type for Canagliflozin
Sponsor	Trials
Industry	95
Other	31
NIH	3

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