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Last Updated: June 26, 2022

CLINICAL TRIALS PROFILE FOR CANAGLIFLOZIN


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All Clinical Trials for Canagliflozin

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00642278 ↗ An Efficacy, Safety, and Tolerability Study of Canagliflozin (JNJ-28431754) in Patients With Type 2 Diabetes Completed Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Phase 2 2008-04-01 The purpose of this study is to evaluate the effectiveness, safety, and tolerability of JNJ-28431754 compared with placebo in patients with type 2 diabetes.
NCT00650806 ↗ A Study of the Safety and Effectiveness of Canagliflozin (JNJ-28431754) in Promoting Weight Loss in Overweight and Obese Patients Who do Not Have Diabetes Completed Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Phase 2 2008-05-01 The purpose of this study is to test the safety and effectiveness of JNJ-28431754 in promoting weight loss in patients who are overweight or obese and who do not have diabetes.
NCT00963768 ↗ A Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Study of JNJ-28431754 in Patients With Type 2 Diabetes Mellitus Completed Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Phase 1 2007-06-01 The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (ie, blood levels of JNJ-28431754) and pharmacodynamics (ie, urine and blood levels of glucose) of JNJ-28431754 compared to placebo in patients with Type 2 diabetes mellitus.
NCT00968812 ↗ CANagliflozin Treatment And Trial Analysis-Sulfonylurea (CANTATA-SU) SGLT2 Add-on to Metformin Versus Glimepiride Completed Janssen Research & Development, LLC Phase 3 2009-09-01 The purpose of this study is to demonstrate the efficacy, safety, and tolerability of canagliflozin (JNJ-28431754) compared with glimepiride in patients with type 2 diabetes mellitus with inadequate control despite treatment with metformin.
NCT01032629 ↗ CANVAS - CANagliflozin cardioVascular Assessment Study Completed The George Institute for Global Health, Australia Phase 3 2009-12-09 The study will assess canagliflozin (JNJ-28431754) in the treatment of patients with type 2 diabetes mellitus (T2DM) with regard to cardiovascular (CV) risk for major adverse cardiac events (MACE). Other objectives include evaluating the overall safety, tolerability, and effectiveness of canagliflozin. The data from this study will be combined with the data from CANVAS-R study (Study of the Effects of Canagliflozin on Renal Endpoints in Adult Subjects with T2DM, NCT01989754) in a pre-specified integrated analysis of CV safety outcomes to satisfy US FDA post-marketing requirements for canagliflozin.
NCT01032629 ↗ CANVAS - CANagliflozin cardioVascular Assessment Study Completed Janssen Research & Development, LLC Phase 3 2009-12-09 The study will assess canagliflozin (JNJ-28431754) in the treatment of patients with type 2 diabetes mellitus (T2DM) with regard to cardiovascular (CV) risk for major adverse cardiac events (MACE). Other objectives include evaluating the overall safety, tolerability, and effectiveness of canagliflozin. The data from this study will be combined with the data from CANVAS-R study (Study of the Effects of Canagliflozin on Renal Endpoints in Adult Subjects with T2DM, NCT01989754) in a pre-specified integrated analysis of CV safety outcomes to satisfy US FDA post-marketing requirements for canagliflozin.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Canagliflozin

Condition Name

Condition Name for Canagliflozin
Intervention Trials
Healthy 40
Diabetes Mellitus, Type 2 36
Type 2 Diabetes Mellitus 12
Type 2 Diabetes 6
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Condition MeSH

Condition MeSH for Canagliflozin
Intervention Trials
Diabetes Mellitus 60
Diabetes Mellitus, Type 2 59
Kidney Diseases 7
Diabetic Nephropathies 5
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Clinical Trial Locations for Canagliflozin

Trials by Country

Trials by Country for Canagliflozin
Location Trials
United States 605
Canada 62
India 22
Mexico 18
Germany 14
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Trials by US State

Trials by US State for Canagliflozin
Location Trials
Florida 32
California 30
Texas 29
Arizona 26
Ohio 22
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Clinical Trial Progress for Canagliflozin

Clinical Trial Phase

Clinical Trial Phase for Canagliflozin
Clinical Trial Phase Trials
Phase 4 33
Phase 3 23
Phase 2/Phase 3 1
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Clinical Trial Status

Clinical Trial Status for Canagliflozin
Clinical Trial Phase Trials
Completed 94
Recruiting 14
Not yet recruiting 9
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Clinical Trial Sponsors for Canagliflozin

Sponsor Name

Sponsor Name for Canagliflozin
Sponsor Trials
Janssen Research & Development, LLC 41
Johnson & Johnson Pharmaceutical Research & Development, L.L.C. 31
Janssen Scientific Affairs, LLC 8
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Sponsor Type

Sponsor Type for Canagliflozin
Sponsor Trials
Industry 101
Other 76
NIH 6
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