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Generated: December 14, 2018

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CLINICAL TRIALS PROFILE FOR BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE

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Clinical Trials for Bupivacaine Hydrochloride And Epinephrine

Trial ID Title Status Sponsor Phase Summary
NCT00298571 Cesarean Delivery and Post-operative Pain Management With Local Anesthesia Completed University of South Florida Phase 2/Phase 3 The use of .5% Bupivacaine with epinephrine at the time of skin closure in cesarean deliveries will decrease post-op pain.
NCT00458003 Phenylephrine in Spinal Anesthesia in Preeclamptic Patients Recruiting Northwestern University N/A Hypotension remains a common clinical problem after induction of spinal anesthesia for cesarean delivery. Maternal hypotension has been associated with considerable morbidity (maternal nausea and vomiting and fetal/neonatal acidemia). Traditionally, ephedrine has been the vasopressor of choice because of concerns about phenylephrine's potential adverse effect on uterine blood flow. This practice was based on animal studies which showed that ephedrine maintained cardiac output and uterine blood flow, while direct acting vasoconstrictors, e.g., phenylephrine, decreased uteroplacental perfusion. However, several recent studies have demonstrated that phenylephrine has similar efficacy to ephedrine for preventing and treating hypotension and may be associated with a lower incidence of fetal acidosis. All of these studies have been performed in healthy patients undergoing elective cesarean delivery. Preeclampsia complicates 5-6% of all pregnancies and is a significant contributor to maternal and fetal morbidity and mortality. Many preeclamptic patients require cesarean delivery of the infant. These patients often have uteroplacental insufficiency. Given the potential for significant hypotension after spinal anesthesia and its effect on an already compromised fetus, prevention of (relative) hypotension in preeclamptic patients is important. Spinal anesthesia in preeclamptic patients has been shown to have no adverse neonatal outcomes as compared to epidural anesthesia when hypotension is treated adequately. Due to problems related to management of the difficult airway and coagulopathy, both of which are more common in preeclamptic women, spinal anesthesia may be the preferred regional anesthesia technique. Recent studies have demonstrated that preeclamptic patients may experience less hypotension after spinal anesthesia than their healthy counterparts. To our knowledge, phenylephrine for the treatment of spinal anesthesia-induced hypotension has not been studied in women with preeclampsia. The aim of our study is to compare intravenous infusion regimens of phenylephrine versus ephedrine for the treatment of spinal anesthesia induced hypotension in preeclamptic patients undergoing cesarean delivery. The primary outcome variable is umbilical artery pH.
NCT00531349 Regional Anesthesia and Endometrial Cancer Recurrence Withdrawn The Cleveland Clinic Phase 3 The purpose of this study is to determine whether recurrence of local and metastatic cancer after open hysterectomy for stage 1 or 2 endometrial cancer is reduced when patients receive epidural anesthesia/analgesia combined with propofol sedation rather than sevoflurane anesthesia and opioid analgesia.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Bupivacaine Hydrochloride And Epinephrine

Condition Name

Condition Name for Bupivacaine Hydrochloride And Epinephrine
Intervention Trials
Pain 14
Postoperative Pain 10
Pain, Postoperative 7
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Condition MeSH

Condition MeSH for Bupivacaine Hydrochloride And Epinephrine
Intervention Trials
Pain, Postoperative 23
Osteoarthritis 8
Osteoarthritis, Knee 3
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Clinical Trial Locations for Bupivacaine Hydrochloride And Epinephrine

Trials by Country

Trials by Country for Bupivacaine Hydrochloride And Epinephrine
Location Trials
United States 55
Canada 9
Brazil 6
Egypt 3
Korea, Republic of 2
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Trials by US State

Trials by US State for Bupivacaine Hydrochloride And Epinephrine
Location Trials
Texas 7
New York 5
California 4
Illinois 4
Minnesota 3
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Clinical Trial Progress for Bupivacaine Hydrochloride And Epinephrine

Clinical Trial Phase

Clinical Trial Phase for Bupivacaine Hydrochloride And Epinephrine
Clinical Trial Phase Trials
Phase 4 35
Phase 3 5
Phase 2/Phase 3 1
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Clinical Trial Status

Clinical Trial Status for Bupivacaine Hydrochloride And Epinephrine
Clinical Trial Phase Trials
Completed 38
Recruiting 24
Not yet recruiting 13
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Clinical Trial Sponsors for Bupivacaine Hydrochloride And Epinephrine

Sponsor Name

Sponsor Name for Bupivacaine Hydrochloride And Epinephrine
Sponsor Trials
Federal University of São Paulo 6
University of Minnesota - Clinical and Translational Science Institute 4
Pacira Pharmaceuticals, Inc 3
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Sponsor Type

Sponsor Type for Bupivacaine Hydrochloride And Epinephrine
Sponsor Trials
Other 98
Industry 6
U.S. Fed 6
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