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Last Updated: March 28, 2024

CLINICAL TRIALS PROFILE FOR BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE


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All Clinical Trials for Bupivacaine Hydrochloride And Epinephrine

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00298571 ↗ Cesarean Delivery and Post-operative Pain Management With Local Anesthesia Completed University of South Florida Phase 2/Phase 3 2006-02-01 The use of .5% Bupivacaine with epinephrine at the time of skin closure in cesarean deliveries will decrease post-op pain.
NCT00458003 ↗ Phenylephrine in Spinal Anesthesia in Preeclamptic Patients Completed Northwestern University N/A 2006-07-01 Hypotension remains a common clinical problem after induction of spinal anesthesia for cesarean delivery. Maternal hypotension has been associated with considerable morbidity (maternal nausea and vomiting and fetal/neonatal acidemia). Traditionally, ephedrine has been the vasopressor of choice because of concerns about phenylephrine's potential adverse effect on uterine blood flow. This practice was based on animal studies which showed that ephedrine maintained cardiac output and uterine blood flow, while direct acting vasoconstrictors, e.g., phenylephrine, decreased uteroplacental perfusion. However, several recent studies have demonstrated that phenylephrine has similar efficacy to ephedrine for preventing and treating hypotension and may be associated with a lower incidence of fetal acidosis. All of these studies have been performed in healthy patients undergoing elective cesarean delivery. Preeclampsia complicates 5-6% of all pregnancies and is a significant contributor to maternal and fetal morbidity and mortality. Many preeclamptic patients require cesarean delivery of the infant. These patients often have uteroplacental insufficiency. Given the potential for significant hypotension after spinal anesthesia and its effect on an already compromised fetus, prevention of (relative) hypotension in preeclamptic patients is important. Spinal anesthesia in preeclamptic patients has been shown to have no adverse neonatal outcomes as compared to epidural anesthesia when hypotension is treated adequately. Due to problems related to management of the difficult airway and coagulopathy, both of which are more common in preeclamptic women, spinal anesthesia may be the preferred regional anesthesia technique. Recent studies have demonstrated that preeclamptic patients may experience less hypotension after spinal anesthesia than their healthy counterparts. To our knowledge, phenylephrine for the treatment of spinal anesthesia-induced hypotension has not been studied in women with preeclampsia. The aim of our study is to compare intravenous infusion regimens of phenylephrine versus ephedrine for the treatment of spinal anesthesia induced hypotension in preeclamptic patients undergoing cesarean delivery. The primary outcome variable is umbilical artery pH.
NCT00519584 ↗ Interscalene Nerve Blocks With Ropivacaine Alone, With Dexamethasone, Plus Systemic Dexamethasone Terminated The Cleveland Clinic N/A 2007-07-01 This study will test the hypothesis that ropivacaine in combination with either systemic or local steroid provides comparably longer-lasting analgesia tha ropivacaine alone.
NCT00531349 ↗ Regional Anesthesia and Endometrial Cancer Recurrence Withdrawn The Cleveland Clinic Phase 3 2007-11-01 The purpose of this study is to determine whether recurrence of local and metastatic cancer after open hysterectomy for stage 1 or 2 endometrial cancer is reduced when patients receive epidural anesthesia/analgesia combined with propofol sedation rather than sevoflurane anesthesia and opioid analgesia.
NCT00636415 ↗ Intra-Articular Morphine Versus Bupivacaine on Knee Motion in Patients With Osteoarthritis Completed Federal University of São Paulo N/A 2004-06-01 CONTEXT AND OBJECTIVE: Osteoarthritis causes pain and disability in a high percentage of elderly people. The aim of the present study was to compare the analgesic effect of intra-articular bupivacaine and morphine in patients with knee osteoarthritis. DESIGN AND SETTING: A randomized and double-blind study was performed at a Pain Clinic of São Paulo Federal University. METHODS: Thirty-nine patients with pain for more than 3 months and an intensity higher than 3 on a numerical scale (zero to 10) were included. G1 patients received 1 mg (1 ml) morphine diluted in 9 ml saline by the intra-articular route, and G2 patients received 25 mg (10 ml) 0.25% bupivacaine without epinephrine. Pain was assessed on a numerical scale and knee flexion and extension angles were measured after administration of the drugs at rest and during movement. The total amount of analgesic complementation with 500 mg paracetamol was also determined.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Bupivacaine Hydrochloride And Epinephrine

Condition Name

Condition Name for Bupivacaine Hydrochloride And Epinephrine
Intervention Trials
Postoperative Pain 21
Pain, Postoperative 21
Pain 16
Analgesia 9
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Condition MeSH

Condition MeSH for Bupivacaine Hydrochloride And Epinephrine
Intervention Trials
Pain, Postoperative 51
Acute Pain 11
Osteoarthritis 10
Osteoarthritis, Knee 5
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Clinical Trial Locations for Bupivacaine Hydrochloride And Epinephrine

Trials by Country

Trials by Country for Bupivacaine Hydrochloride And Epinephrine
Location Trials
United States 84
Canada 19
Egypt 13
Brazil 6
Korea, Republic of 3
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Trials by US State

Trials by US State for Bupivacaine Hydrochloride And Epinephrine
Location Trials
New York 8
Texas 8
North Carolina 7
Massachusetts 7
California 7
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Clinical Trial Progress for Bupivacaine Hydrochloride And Epinephrine

Clinical Trial Phase

Clinical Trial Phase for Bupivacaine Hydrochloride And Epinephrine
Clinical Trial Phase Trials
Phase 4 65
Phase 3 8
Phase 2/Phase 3 3
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Clinical Trial Status

Clinical Trial Status for Bupivacaine Hydrochloride And Epinephrine
Clinical Trial Phase Trials
Completed 72
Recruiting 25
Not yet recruiting 21
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Clinical Trial Sponsors for Bupivacaine Hydrochloride And Epinephrine

Sponsor Name

Sponsor Name for Bupivacaine Hydrochloride And Epinephrine
Sponsor Trials
Federal University of São Paulo 6
University of California, San Diego 5
University of Minnesota 4
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Sponsor Type

Sponsor Type for Bupivacaine Hydrochloride And Epinephrine
Sponsor Trials
Other 188
Industry 10
U.S. Fed 6
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