CLINICAL TRIALS PROFILE FOR BRIMONIDINE TARTRATE AND TIMOLOL MALEATE

All Clinical Trials for Brimonidine Tartrate And Timolol Maleate

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT00435058 ↗	Visual Function Changes After Intraocular Pressure Reduction	Completed	University of Sao Paulo	N/A	2005-09-01	During the glaucomatous disease process, subpopulations of cells may be dead, damaged or healthy. Visual function changes could be observed due to a recovering of the suffering ganglion cells after the intraocular pressure reduction. This study aims at evaluating the correlation between intraocular pressure reduction and visual function changes in glaucoma patients after using antiglaucoma medications.
NCT00698945 ↗	Comparison of Istalol™ 0.5% QD (Timolol Maleate/Sorbitol Complex, ISTA Pharmaceutical) to Brimonidine Tartrate 0.1% BID as Adjunctive Therapy to Latanoprost 0.005% in Adults With Ocular Hypertension (OHT) or Open-Angle Glaucoma (OAG)	Completed	Bp Consulting, Inc	Phase 4	2008-06-01	To assess the additional benefit of common adjunctive classes on the diurnal IOP curve in patients assessed as needing additional treatment to reach target intraocular pressure (IOP). To demonstrate superiority of IOP control with Istalol 0.5% QD compared to Brimonidine Tartrate 0.2% BID as adjunctive therapy in adults with uncontrolled IOP's (determined by P.I. based on target pressures) currently treated with Latanoprost 0.05% in the study eye(s).
NCT00811564 ↗	An Evaluation of the Fixed Combination Brimonidine Tartrate 0.2%/ Timolol Maleate 0.5% to Latanoprost 0.005% in Glaucoma or Ocular Hypertension Subjects	Completed	Allergan	Phase 4	2008-12-01	A three-month evaluation comparing the safety and efficacy of a fixed combination of 0.2% brimonidine tartrate/0.5% timolol maleate with that of latanoprost 0.005%, a prostaglandin analogue in glaucoma or ocular hypertension subjects
NCT00811850 ↗	Comparing Effects of Two Fixed Combinations Ophthalmic Solutions on Ocular Blood Flow	Completed	Allergan	Phase 4	2008-12-01	A 10 week evaluation, crossover design study including a 3 week washout period between treatments, to determine the effects of Combigan® (fixed combination brimonidine tartrate 0.2%/timolol maleate 0.5%) and Cosopt® (fixed combination dorzolamide hydrochloride-timolol maleate ophthalmic solutions) on ocular blood flow as measured by retrobulbar blood flow.
NCT01284166 ↗	Safety and Efficacy of Triple Combination Therapy With Dorzolamide Hydrochloride / Brimonidine Tartrate / Timolol Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension	Withdrawn	Allergan	Phase 3	2013-07-01	This study will investigate the safety and efficacy of Triple Combination Therapy with dorzolamide hydrochloride/brimonidine tartrate/timolol ophthalmic solution in patients with glaucoma or ocular hypertension who have elevated IOP on dorzolamide hydrochloride/timolol maleate combination therapy.
NCT01987752 ↗	Safety and Efficacy of Combigan® Ophthalmic Solution in Korea	Completed	Allergan		2009-01-01	This study is a Post-Marketing Surveillance study in Korea to evaluate the safety and efficacy of Combigan® (brimonidine tartrate/timolol maleate) Ophthalmic Solution in patients with Open Angle Glaucoma or Ocular hypertension with insufficient response to local beta blockers treated as per standard of care in clinical practice.

Clinical Trial Conditions for Brimonidine Tartrate And Timolol Maleate

Condition Name

Condition Name for Brimonidine Tartrate And Timolol Maleate
Intervention	Trials
Glaucoma	4
Ocular Hypertension	4
Glaucoma, Open-Angle	1
Open-Angle Glaucoma	1

Condition MeSH

Condition MeSH for Brimonidine Tartrate And Timolol Maleate
Intervention	Trials
Glaucoma	5
Ocular Hypertension	4
Hypertension	3
Glaucoma, Open-Angle	2

Clinical Trial Locations for Brimonidine Tartrate And Timolol Maleate

Trials by Country

Trials by Country for Brimonidine Tartrate And Timolol Maleate
Location	Trials
United States	3
Korea, Republic of	1

Trials by US State

Trials by US State for Brimonidine Tartrate And Timolol Maleate
Location	Trials
Indiana	1
New York	1
California	1

Clinical Trial Progress for Brimonidine Tartrate And Timolol Maleate

Clinical Trial Phase

Clinical Trial Phase for Brimonidine Tartrate And Timolol Maleate
Clinical Trial Phase	Trials
Phase 4	3
Phase 3	1
N/A	1

Clinical Trial Status

Clinical Trial Status for Brimonidine Tartrate And Timolol Maleate
Clinical Trial Phase	Trials
Completed	5
Withdrawn	1

Clinical Trial Sponsors for Brimonidine Tartrate And Timolol Maleate

Sponsor Name

Sponsor Name for Brimonidine Tartrate And Timolol Maleate
Sponsor	Trials
Allergan	4
University of Sao Paulo	1
Bp Consulting, Inc	1

Sponsor Type

Sponsor Type for Brimonidine Tartrate And Timolol Maleate
Sponsor	Trials
Industry	4
Other	2