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Generated: December 16, 2018

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CLINICAL TRIALS PROFILE FOR BRIMONIDINE TARTRATE

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Clinical Trials for Brimonidine Tartrate

Trial ID Title Status Sponsor Phase Summary
NCT00061529 A Phase III Study of Brimonidine Tartrate Ophthalmic Solution, 0.15% in Patients With Open-Angle Glaucoma or Ocular Hypertension Completed Alcon Research Phase 3 The primary objective of this study is to compare the safety and efficacy of Brimonidine Tartrate Ophthalmic Solution, 0.15% in patients with open-angle glaucoma or ocular hypertension.
NCT00121147 Additivity Study: Additive Effect on Eye Pressure of Azopt and Alphagan P to Travatan Completed Alcon Research N/A The purpose of this study is to compare the additive effect on eye pressure of Azopt and Alphagan P to Travatan.
NCT00121147 Additivity Study: Additive Effect on Eye Pressure of Azopt and Alphagan P to Travatan Completed Hermann Eye Center N/A The purpose of this study is to compare the additive effect on eye pressure of Azopt and Alphagan P to Travatan.
NCT00312416 Effects of Topical Clonidine vs. Brimonidine on Choroidal Blood Flow and Intraocular Pressure During Isometric Exercise Completed Medical University of Vienna Phase 4 Brimonidine tartrate is an alpha-2 agonist ocular hypotensive drug that exerts its effect by causing both a decrease in aqueous production and an increase in uveoscleral outflow. It has been proven to reduce increased intraocular pressure in glaucoma and ocular hypertension. As an alpha 2 agonist Brimonidine belongs to the same class of drugs as Clonidine; however, its molecular structure is sufficiently different to make it more selective for the alpha 2 receptor than Clonidine. Unlike Clonidine, Brimonidine does not appear to have an effect on the central nervous system and therefore does not cause sedation or systemic hypotension. In addition to their known effect of lowering intraocular pressure, alpha 2 adrenoceptor agonists are neuroprotective. It has, however, been shown that Brimonidine is a very potent vasoconstrictor in the ciliary body thus reducing aqueous humor production. Little is, however, known about potential vasoconstrictor effects of Brimonidine in the posterior pole of the eye. This is of clinical importance, because optic nerve head ischemia appears to contribute to glaucoma pathophysiology. This study is performed to investigate the effects of topical Clonidine vs. topical Brimonidine on choroidal blood flow and intraocular pressure during isometric exercise.
NCT00413751 Effect of Brimonidine Tartrate Ophthalmic Solution 0.15% on Pupil Diameter in Normal Eyes Completed Walter Reed Army Medical Center N/A The objective of this study is to evaluate the effect of brimonidine tartrate ophthalmic solution 0.15% (Alphagan P) on pupil diameter under different luminance conditions.
NCT00435058 Visual Function Changes After Intraocular Pressure Reduction Completed University of Sao Paulo N/A During the glaucomatous disease process, subpopulations of cells may be dead, damaged or healthy. Visual function changes could be observed due to a recovering of the suffering ganglion cells after the intraocular pressure reduction. This study aims at evaluating the correlation between intraocular pressure reduction and visual function changes in glaucoma patients after using antiglaucoma medications.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Brimonidine Tartrate

Condition Name

Condition Name for Brimonidine Tartrate
Intervention Trials
Ocular Hypertension 14
Glaucoma 8
Glaucoma, Open-Angle 5
Open-Angle Glaucoma 3
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Condition MeSH

Condition MeSH for Brimonidine Tartrate
Intervention Trials
Glaucoma 17
Ocular Hypertension 15
Hypertension 13
Glaucoma, Open-Angle 12
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Clinical Trial Locations for Brimonidine Tartrate

Trials by Country

Trials by Country for Brimonidine Tartrate
Location Trials
United States 44
Korea, Republic of 4
Brazil 4
Israel 3
India 3
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Trials by US State

Trials by US State for Brimonidine Tartrate
Location Trials
California 5
Texas 4
New York 4
Massachusetts 4
Florida 3
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Clinical Trial Progress for Brimonidine Tartrate

Clinical Trial Phase

Clinical Trial Phase for Brimonidine Tartrate
Clinical Trial Phase Trials
Phase 4 13
Phase 3 10
Phase 2 7
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Clinical Trial Status

Clinical Trial Status for Brimonidine Tartrate
Clinical Trial Phase Trials
Completed 27
Recruiting 8
Unknown status 2
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Clinical Trial Sponsors for Brimonidine Tartrate

Sponsor Name

Sponsor Name for Brimonidine Tartrate
Sponsor Trials
Allergan 14
ORA, Inc. 4
Alcon Research 3
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Sponsor Type

Sponsor Type for Brimonidine Tartrate
Sponsor Trials
Industry 31
Other 18
U.S. Fed 1
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