To Evaluate The Effect Of Ketoconazole, Ritonavir and Erythromycin on the Safety and Pharmacokinetics of Avanafil
This study is being conducted to examine the effect of three CYP3A4 inhibitors
(ketoconazole, erythromycin and ritonavir) on the single dose pharmacokinetics of avanafil.
Ketoconazole and ritonavir are potent inhibitors of CYP3A4 and erythromycin is a moderate
CYP3A4 inhibitor. Any interaction that is observed would be predictive of other inhibitors
Long-Term Safety and Efficacy Study of Avanafil in Men With Erectile Dysfunction
This open-label study is being conducted to evaluate the long-term safety, tolerability, and
efficacy of avanafil in men with mild to severe erectile dysfunction. Approximately 400
subjects will be enrolled and treated with avanafil for up to 52 weeks.
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