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Generated: December 15, 2018

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CLINICAL TRIALS PROFILE FOR ATOVAQUONE; PROGUANIL HYDROCHLORIDE

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Clinical Trials for Atovaquone; Proguanil Hydrochloride

Trial ID Title Status Sponsor Phase Summary
NCT00084227 Azithromycin Plus Chloroquine Versus Atovaquone-Proguanil For The Treatment Of Uncomplicated Plasmodium Falciparum Malaria In South America Completed Pfizer Phase 2/Phase 3 The primary objective is to confirm the hypothesis that azithromycin plus chloroquine is non-inferior to atovaquone-proguanil for the treatment of symptomatic, uncomplicated malaria due to P. falciparum.
NCT00149383 Safety and Efficacy Study of Adjunctive Rosiglitazone in the Treatment of Uncomplicated Falciparum Malaria Completed McLaughlin-Rotman Center for Global Health, University of Toronto Phase 1/Phase 2 The purpose of this study is to examine the safety, tolerability, and efficacy of adjunctive rosiglitazone in the treatment of uncomplicated P.falciparum malaria.
NCT00149383 Safety and Efficacy Study of Adjunctive Rosiglitazone in the Treatment of Uncomplicated Falciparum Malaria Completed Mahidol University Phase 1/Phase 2 The purpose of this study is to examine the safety, tolerability, and efficacy of adjunctive rosiglitazone in the treatment of uncomplicated P.falciparum malaria.
NCT00379821 Chloroquine Alone or in Combination for Malaria in Children in Malawi Completed National Institute of Allergy and Infectious Diseases (NIAID) Phase 3 Malaria is a sickness caused by a germ that can get into a person's body when a mosquito bites them. It can cause fever, headache, body aches and weakness. It can even cause death, especially in children. When malaria is treated with the appropriate medicine(s), it can be cured completely. The purpose of this study is to find out if it is better to use chloroquine alone or in combination with another drug to most effectively treat malaria. About 640 children with malaria, aged 6 months to 5 years of age, from the Blantyre Malaria Project Research Clinic at the Ndirande Health Center in Malawi will be in the study. They will be treated with either chloroquine alone or a combination of chloroquine plus another medication (azithromycin or artesunate or atovaquone-proguanil) every time they get malaria for a year. Blood samples will be collected and tested at least every 4 weeks. Participants will be involved in the study for 1 year.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Atovaquone; Proguanil Hydrochloride

Condition Name

Condition Name for Atovaquone; Proguanil Hydrochloride
Intervention Trials
Malaria 11
Falciparum Malaria 2
Falciparum 2
Malaria, Falciparum 2
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Condition MeSH

Condition MeSH for Atovaquone; Proguanil Hydrochloride
Intervention Trials
Malaria 16
Malaria, Falciparum 6
Toxoplasmosis 1
HIV Infections 1
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Clinical Trial Locations for Atovaquone; Proguanil Hydrochloride

Trials by Country

Trials by Country for Atovaquone; Proguanil Hydrochloride
Location Trials
Netherlands 5
Thailand 3
United States 3
Cambodia 2
Germany 1
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Trials by US State

Trials by US State for Atovaquone; Proguanil Hydrochloride
Location Trials
Maryland 3
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Clinical Trial Progress for Atovaquone; Proguanil Hydrochloride

Clinical Trial Phase

Clinical Trial Phase for Atovaquone; Proguanil Hydrochloride
Clinical Trial Phase Trials
Phase 4 8
Phase 3 2
Phase 2/Phase 3 1
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Clinical Trial Status

Clinical Trial Status for Atovaquone; Proguanil Hydrochloride
Clinical Trial Phase Trials
Completed 13
Recruiting 3
Terminated 2
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Clinical Trial Sponsors for Atovaquone; Proguanil Hydrochloride

Sponsor Name

Sponsor Name for Atovaquone; Proguanil Hydrochloride
Sponsor Trials
Radboud University 3
U.S. Army Medical Research and Materiel Command 2
Armed Forces Research Institute of Medical Sciences, Thailand 2
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Sponsor Type

Sponsor Type for Atovaquone; Proguanil Hydrochloride
Sponsor Trials
Other 25
Industry 6
U.S. Fed 2
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