The objective of the Trial of Antihypertensive Intervention Management (TAIM) was to
determine the efficacy of dietary management and/or drug therapy, namely thiazide-like
diuretics or a beta-blocker, in the control of mild hypertension. Additionally, the
Continuation of the Trial of Antihypertensive Intervention Management (COTAIM) tested the
effects of long-term weight reduction, and sodium/potassium changes added to weight
reduction, as well as the original drug treatment, on the failure rate of blood pressure
Systolic Hypertension in the Elderly Program (SHEP)
National Institute on Aging (NIA)
The primary objective was to assess whether long-term administration of antihypertensive
therapy to elderly subjects with isolated systolic hypertension reduced the combined
incidence of fatal and non-fatal stroke. The secondary objectives were to evaluate: the
effect of long-term antihypertensive therapy on mortality from any cause in elderly people
with isolated systolic hypertension; possible adverse effects of chronic use of
antihypertensive drug treatment in this population; the effect of therapy on indices of
quality-of-life; the natural history of isolated systolic hypertension in the placebo
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