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Generated: March 20, 2019

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CLINICAL TRIALS PROFILE FOR ASPIRIN; OMEPRAZOLE

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Clinical Trials for Aspirin; Omeprazole

Trial ID Title Status Sponsor Phase Summary
NCT00349661 Influence Of Omeprazole On The Anti-Platelet Action Of Clopidogrel Completed University Hospital, Brest Phase 3 Objectives: A prospective investigation of the effect of omeprazole, a proton pump inhibitor, on the anti-platelet action of clopidogrel. The main decision criterion will concern change in VASP protein phosphorylation under treatment. Phosphorylation will be measured before and after administration of omeprazole versus placebo in patients undergoing clopidogrel treatment. Type of study: Single center, double blind, randomized parallel group study versus placebo, comparing two treatment groups: - clopidogrel + omeprazole + standard regime (beta-blockers, atorvastatin, IEC, aspirin) - clopidogrel + placebo+ standard regime (beta-blockers, atorvastatin, IEC, aspirin) Study population: 120 patients from the Cardiology Department of Brest University hospital, Brest (France), receiving a standard treatment comprising a loading dose of clopidogrel followed by a daily dose of 75 mg associated to 75 mg aspirin, will be randomized between 20 mg/day omeprazole and 20 mg/day placebo treatment groups. The efficacy of clopidogrel will be assessed by inter-group comparison on the VASP test. Study period: 7 days' treatment per patient. Total study period estimated at 6 months. Expected findings: The results should confirm the suspected negative effect of omeprazole on clopidogrel's impact on arterial thrombosis risk, secondarily allowing new recommendations to be drawn up for this association.
NCT00441519 A Parallel Group Study to Compare the Gastroprotective Effects of PA 325 Versus 81 mg Enteric Coated Aspirin Completed POZEN Phase 1 To compare the gastroprotective effects of a once-daily dose of PA 325 combination tablet
NCT00442052 To Compare the Gastroprotective Effects and Pharmacokinetic Profile of PA Versus Enteric-Coated Aspirin Completed POZEN Phase 1 Primary: To compare the gastroprotective effects of a once-daily dose of PA 325 combination tablet combining 325 mg pH sensitive aspirin and 20 mg immediate release omeprazole versus a once-daily dose of 325 mg enteric coated aspirin utilizing Lanza scores from endoscopy findings in normal healthy volunteers.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Aspirin; Omeprazole

Condition Name

Condition Name for Aspirin; Omeprazole
Intervention Trials
Healthy 3
Barrett's Esophagus 1
Gastroesophageal Reflux Disease 1
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Condition MeSH

Condition MeSH for Aspirin; Omeprazole
Intervention Trials
Acute Coronary Syndrome 2
Myocardial Ischemia 2
Coronary Disease 2
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Clinical Trial Locations for Aspirin; Omeprazole

Trials by Country

Trials by Country for Aspirin; Omeprazole
Location Trials
United States 48
Canada 9
Australia 6
Mexico 3
France 2
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Trials by US State

Trials by US State for Aspirin; Omeprazole
Location Trials
North Carolina 3
Texas 2
Maryland 2
Florida 2
Alabama 1
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Clinical Trial Progress for Aspirin; Omeprazole

Clinical Trial Phase

Clinical Trial Phase for Aspirin; Omeprazole
Clinical Trial Phase Trials
Phase 4 2
Phase 3 3
Phase 1 7
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Clinical Trial Status

Clinical Trial Status for Aspirin; Omeprazole
Clinical Trial Phase Trials
Completed 11
Unknown status 2
Terminated 1
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Clinical Trial Sponsors for Aspirin; Omeprazole

Sponsor Name

Sponsor Name for Aspirin; Omeprazole
Sponsor Trials
POZEN 4
Hadassah Medical Organization 2
Fundação de Amparo à Pesquisa do Estado de São Paulo 1
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Sponsor Type

Sponsor Type for Aspirin; Omeprazole
Sponsor Trials
Other 9
Industry 7
U.S. Fed 1
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