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Last Updated: July 3, 2022

CLINICAL TRIALS PROFILE FOR ARICEPT


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All Clinical Trials for Aricept

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00000173 ↗ Memory Impairment Study (Mild Cognitive Impairment Study) Completed Alzheimer's Disease Cooperative Study (ADCS) Phase 3 1999-03-01 The National Institute on Aging (NIA) is launching a nationwide treatment study targeting individuals with mild cognitive impairment (MCI), a condition characterized by a memory deficit, but not dementia. An NIA-funded study recently confirmed that MCI is different from both dementia and normal age-related changes in memory. Accurate and early evaluation and treatment of MCI individuals might prevent further cognitive decline, including development of Alzheimer's disease (AD). The Memory Impairment Study is the first such AD prevention clinical trial carried out by NIH, and will be conducted at 65-80 medical research institutions located in the United States and Canada. This study will test the usefulness of two drugs to slow or stop the conversion from MCI to AD. The trial will evaluate placebo, vitamin E, and donepezil, an investigational agent approved by the Food and Drug Administration for another use. Vitamin E (alpha-tocopherol) is thought to have antioxidant properties, and was shown in a 1997 study to delay important dementia milestones, such as patients' institutionalization or progression to severe dementia, by about seven months.
NCT00000173 ↗ Memory Impairment Study (Mild Cognitive Impairment Study) Completed National Institute on Aging (NIA) Phase 3 1999-03-01 The National Institute on Aging (NIA) is launching a nationwide treatment study targeting individuals with mild cognitive impairment (MCI), a condition characterized by a memory deficit, but not dementia. An NIA-funded study recently confirmed that MCI is different from both dementia and normal age-related changes in memory. Accurate and early evaluation and treatment of MCI individuals might prevent further cognitive decline, including development of Alzheimer's disease (AD). The Memory Impairment Study is the first such AD prevention clinical trial carried out by NIH, and will be conducted at 65-80 medical research institutions located in the United States and Canada. This study will test the usefulness of two drugs to slow or stop the conversion from MCI to AD. The trial will evaluate placebo, vitamin E, and donepezil, an investigational agent approved by the Food and Drug Administration for another use. Vitamin E (alpha-tocopherol) is thought to have antioxidant properties, and was shown in a 1997 study to delay important dementia milestones, such as patients' institutionalization or progression to severe dementia, by about seven months.
NCT00004807 ↗ Study of the Pathogenesis of Rett Syndrome Completed Johns Hopkins University N/A 1995-01-01 OBJECTIVES: I. Extend current knowledge of the phenotype and natural history of Rett syndrome (RS). II. Continue the search for a cytogenetic and/or DNA marker. III. Study the effects of cholinergic drugs based on preliminary evidence for reduced levels of brain acetylcholine, while continuing supportive care to modify seizures, respiratory abnormalities, and motor disturbances, and improve nutrition, behavior, and learning. IV. Identify targets for future therapeutic interventions, e.g., growth factors, to influence neurologic recovery.
NCT00004807 ↗ Study of the Pathogenesis of Rett Syndrome Completed Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) N/A 1995-01-01 OBJECTIVES: I. Extend current knowledge of the phenotype and natural history of Rett syndrome (RS). II. Continue the search for a cytogenetic and/or DNA marker. III. Study the effects of cholinergic drugs based on preliminary evidence for reduced levels of brain acetylcholine, while continuing supportive care to modify seizures, respiratory abnormalities, and motor disturbances, and improve nutrition, behavior, and learning. IV. Identify targets for future therapeutic interventions, e.g., growth factors, to influence neurologic recovery.
NCT00018278 ↗ Electrophysiologic Measures of Treatment Response in Alzheimer Disease Completed US Department of Veterans Affairs Phase 4 1998-10-01 The main purpose of this study is to determine the electrophysiological effects of cholinergic therapy (cholinesterase inhibitors and transdermal nicotine) in Alzheimer disease. The attempt will be to locate electrophysiological markers and predictors of cognitive and clinical treatment response.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Aricept

Condition Name

Condition Name for Aricept
Intervention Trials
Alzheimer's Disease 36
Alzheimer Disease 20
Healthy 14
Dementia 10
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Condition MeSH

Condition MeSH for Aricept
Intervention Trials
Alzheimer Disease 64
Dementia 25
Cognitive Dysfunction 19
Cognition Disorders 15
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Clinical Trial Locations for Aricept

Trials by Country

Trials by Country for Aricept
Location Trials
United States 340
Canada 46
Japan 28
Korea, Republic of 23
United Kingdom 23
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Trials by US State

Trials by US State for Aricept
Location Trials
California 25
Florida 21
Texas 21
New York 18
Arizona 17
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Clinical Trial Progress for Aricept

Clinical Trial Phase

Clinical Trial Phase for Aricept
Clinical Trial Phase Trials
Phase 4 32
Phase 3 21
Phase 2 36
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Clinical Trial Status

Clinical Trial Status for Aricept
Clinical Trial Phase Trials
Completed 111
Terminated 16
Unknown status 7
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Clinical Trial Sponsors for Aricept

Sponsor Name

Sponsor Name for Aricept
Sponsor Trials
Pfizer 18
Eisai Inc. 15
National Institute of Mental Health (NIMH) 9
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Sponsor Type

Sponsor Type for Aricept
Sponsor Trials
Industry 115
Other 89
NIH 25
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