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Last Updated: November 12, 2019

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CLINICAL TRIALS PROFILE FOR ARALEN HYDROCHLORIDE

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All Clinical Trials for Aralen Hydrochloride

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00224978 Chloroquine for Treatment of Glioblastoma Multiforme Completed National Institute of Neurology and Neurosurgery, Mexico Phase 3 2005-01-01 Chloroquine is a strong lysosomotropic and DNA-intercalating agent in experimental studies (Neurosurgical Focus 14(2): February, 2003) and an open-label clinical trial the investigators have demonstrated a strong adjuvant effect of chloroquine on the therapy of malignant gliomas. This study will assess in a randomized, placebo-controlled, double-blind study the effects of chloroquine as adjuvant to the conventional therapy of Glioblastoma Multiforme.
NCT00323375 Phase 1 Studies of AQ-13, a Candidate Aminoquinoline Antimalarial, in Comparison With Chloroquine Completed National Institutes of Health (NIH) Phase 1 1999-08-01 The purpose of this protocol is to perform Phase 1 (safety/toxicity and pharmacokinetic) Studies of an investigational aminoquinoline antimalarial (AQ-13) in human subjects. The compound to be studied (AQ-13) is being examined because it is active in vitro against Plasmodium falciparum malaria parasites resistant to chloroquine (CQ) and other antimalarials (multi-resistant P. falciparum), and because its safety was similar to that of CQ in preclinical studies performed by SRI International (IND 55,670). AQ-13 was also selected for study because it is active in vivo in two monkey models of human malaria: 1] P. cynomolgi in the rhesus monkey (Macaca mulatta), a model of human infection with P. vivax, and 2] CQ-resistant P. falciparum in the squirrel monkey, a model of human infection with CQ-resistant P. falciparum.
NCT00323375 Phase 1 Studies of AQ-13, a Candidate Aminoquinoline Antimalarial, in Comparison With Chloroquine Completed Tulane University Health Sciences Center Phase 1 1999-08-01 The purpose of this protocol is to perform Phase 1 (safety/toxicity and pharmacokinetic) Studies of an investigational aminoquinoline antimalarial (AQ-13) in human subjects. The compound to be studied (AQ-13) is being examined because it is active in vitro against Plasmodium falciparum malaria parasites resistant to chloroquine (CQ) and other antimalarials (multi-resistant P. falciparum), and because its safety was similar to that of CQ in preclinical studies performed by SRI International (IND 55,670). AQ-13 was also selected for study because it is active in vivo in two monkey models of human malaria: 1] P. cynomolgi in the rhesus monkey (Macaca mulatta), a model of human infection with P. vivax, and 2] CQ-resistant P. falciparum in the squirrel monkey, a model of human infection with CQ-resistant P. falciparum.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Aralen Hydrochloride

Condition Name

Condition Name for Aralen Hydrochloride
Intervention Trials
Malaria 2
DCIS 1
Hyper-reactive Malarial Splenomegaly 1
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Condition MeSH

Condition MeSH for Aralen Hydrochloride
Intervention Trials
Neoplasms 1
Overweight 1
Carcinoma, Intraductal, Noninfiltrating 1
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Clinical Trial Locations for Aralen Hydrochloride

Trials by Country

Trials by Country for Aralen Hydrochloride
Location Trials
United States 6
Netherlands 2
Mexico 2
Malawi 1
Papua New Guinea 1
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Trials by US State

Trials by US State for Aralen Hydrochloride
Location Trials
Ohio 1
New York 1
Connecticut 1
Virginia 1
Missouri 1
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Clinical Trial Progress for Aralen Hydrochloride

Clinical Trial Phase

Clinical Trial Phase for Aralen Hydrochloride
Clinical Trial Phase Trials
Phase 3 2
Phase 2 3
Phase 1/Phase 2 2
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Clinical Trial Status

Clinical Trial Status for Aralen Hydrochloride
Clinical Trial Phase Trials
Completed 4
Recruiting 3
Active, not recruiting 2
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Clinical Trial Sponsors for Aralen Hydrochloride

Sponsor Name

Sponsor Name for Aralen Hydrochloride
Sponsor Trials
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) 1
George Mason University 1
Millennium Pharmaceuticals, Inc. 1
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Sponsor Type

Sponsor Type for Aralen Hydrochloride
Sponsor Trials
Other 12
NIH 3
U.S. Fed 2
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