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Last Updated: February 26, 2020

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CLINICAL TRIALS PROFILE FOR AMINOHIPPURATE SODIUM

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All Clinical Trials for Aminohippurate Sodium

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00722215 Endothelin Receptor Antagonism in Proteinuric Nephropathy Completed British Heart Foundation Phase 1 2006-05-01 The number of people with kidney problems is increasing rapidly, related in part to the increasing prevalence of diabetes. Patients with kidney problems tend to have protein leaking into the urine (proteinuria). Both proteinuria and the kidney disease itself are associated with an increased risk of heart disease. Reducing proteinuria is an important treatment goal in people with kidney problems. Endothelin is a chemical produced both by blood vessels and the kidney. Higher than normal levels of endothelin are thought to contribute to progression of kidney disease and proteinuria. By using drugs that block the effects of endothelin ('endothelin receptor antagonists') we can hopefully reduce both of these. The purpose of the study is to ascertain whether endothelin receptor antagonists improve kidney function and reduce proteinuria more so than other commonly used drugs.
NCT00722215 Endothelin Receptor Antagonism in Proteinuric Nephropathy Completed University of Edinburgh Phase 1 2006-05-01 The number of people with kidney problems is increasing rapidly, related in part to the increasing prevalence of diabetes. Patients with kidney problems tend to have protein leaking into the urine (proteinuria). Both proteinuria and the kidney disease itself are associated with an increased risk of heart disease. Reducing proteinuria is an important treatment goal in people with kidney problems. Endothelin is a chemical produced both by blood vessels and the kidney. Higher than normal levels of endothelin are thought to contribute to progression of kidney disease and proteinuria. By using drugs that block the effects of endothelin ('endothelin receptor antagonists') we can hopefully reduce both of these. The purpose of the study is to ascertain whether endothelin receptor antagonists improve kidney function and reduce proteinuria more so than other commonly used drugs.
NCT00962286 Effect of Furosemide on Obesity-induced Glomerular Hyperfiltration Terminated Rabin Medical Center N/A 2009-09-01 Background: Obesity is associated with a high prevalence of chronic kidney disease. The glomerular hyperfiltration associated with obesity may play a role in the pathogenesis of obesity associated chronic kidney disease. Attenuation of hyperfiltration by pharmacological means may slow down the development and progression of chronic renal failure. The investigators have previously shown that acetazolamide, a proximally acting diuretic that activates TGF by increasing solute delivery to the macula densa, abates glomerular hyperfiltration. The present study was designed to test the hypothesis that this decrease in hyperfiltration is specific to acetazolamide and not due to a non specific diuretic effect. The aim of the present study is to evaluate the effects of the administration of furosemide p.o. to subjects with severe obesity on glomerular hemodynamics. Methods: Ten obese subjects will participate in the study. They will undergo measurement of glomerular filtration rate (inulin clearance) (GFR), renal plasma flow (RPF) (p-aminohippuric acid clearance), filtration fraction, fractional excretion of lithium (FE LI) and blood pressure, before and after administration of oral furosemide 20 to 40 mg bid for 3 days. The effects of furosemide on glomerular hemodynamics in obese subjects will be compared to the previously studied effects of acetazolamide.
NCT01146288 Effect of Acetazolamide and Furosemide on Obesity-induced Glomerular Hyperfiltration Completed Rabin Medical Center N/A 2010-07-01 Background: Obesity is associated with a high prevalence of chronic kidney disease.The glomerular hyperfiltration associated with obesity may play a role in the pathogenesis of obesity associated chronic kidney disease. Attenuation of hyperfiltration by pharmacological means may slow down the development and progression of chronic renal failure. The investigators have previously shown that acetazolamide, a proximally acting diuretic that activates tubuloglomerular feedback(TGF) by increasing solute delivery to the Macula DENSA, abates glomerular hyperfiltration. The present study was designed to test the hypothesis that this decrease in hyperfiltration is specific to acetazolamide and not due to a non specific diuretic effect. The aim of the present study is to compare the effects of furosemide and acetazolamide on glomerular hemodynamics in subjects with severe obesity. Methods: A randomized double-blind crossover controlled design will be used. Fifteen obese subjects and ten subjects with normal body weight will participate in the study. Obese subjects will undergo measurement of glomerular filtration rate (GFR)(inulin clearance), renal plasma flow (RPF) (p-aminohippuric acid clearance), filtration fraction, fractional excretion of lithium (FE LI) and blood pressure, before and after intravenous administration of furosemide 2 mg. and acetazolamide 5 mg/kg BW. Ten subjects with normal body weight will undergo measurement of renal function without administration of diuretics.
NCT01156220 Investigation of Gender Specificity of the Effects of Furosemide in Healthy Female and Male Volunteers Unknown status Universitätsklinikum Hamburg-Eppendorf Phase 4 2012-01-01 In this study the gender specificity of the effects of furosemide in female and male volunteers will be investigated. The healthy volunteers receive 1. furosemide and 2. aminohippurate sodium "PAH" as single dose. The main objective is gender-specific comparison of the pharmacokinetic parameters of furosemide in relation to the effect of furosemide (urinary excretion). Secondary objectives are the gender-specific comparison of renal and systemic PAH clearance with the clearance of furosemide and the influence of various genetic polymorphisms on the variability of furosemide pharmacokinetics.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Aminohippurate Sodium

Condition Name

Condition Name for Aminohippurate Sodium
Intervention Trials
Obesity-induced Hyperfiltration 2
Prediabetic State 1
Obesity 1
Healthy Male and Female Volunteers 1
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Condition MeSH

Condition MeSH for Aminohippurate Sodium
Intervention Trials
Obesity 2
Renal Insufficiency, Chronic 1
Proteinuria 1
Diabetic Nephropathies 1
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Clinical Trial Locations for Aminohippurate Sodium

Trials by Country

Trials by Country for Aminohippurate Sodium
Location Trials
Israel 2
United Kingdom 1
Netherlands 1
Germany 1
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Clinical Trial Progress for Aminohippurate Sodium

Clinical Trial Phase

Clinical Trial Phase for Aminohippurate Sodium
Clinical Trial Phase Trials
Phase 4 2
Phase 1 1
N/A 3
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Clinical Trial Status

Clinical Trial Status for Aminohippurate Sodium
Clinical Trial Phase Trials
Completed 2
Not yet recruiting 1
Recruiting 1
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Clinical Trial Sponsors for Aminohippurate Sodium

Sponsor Name

Sponsor Name for Aminohippurate Sodium
Sponsor Trials
Rabin Medical Center 2
University of Edinburgh 1
British Heart Foundation 1
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Sponsor Type

Sponsor Type for Aminohippurate Sodium
Sponsor Trials
Other 7
Industry 1
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