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Generated: December 14, 2018

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CLINICAL TRIALS PROFILE FOR AMBRISENTAN

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Clinical Trials for Ambrisentan

Trial ID Title Status Sponsor Phase Summary
NCT00091598 ARIES - Ambrisentan in Patients With Moderate to Severe Pulmonary Arterial Hypertension (PAH) Completed Gilead Sciences Phase 3 The primary objective is to determine the effect of ambrisentan on exercise capacity in subjects with PAH.
NCT00380068 Safety and Efficacy Study of Ambrisentan in Subjects With Pulmonary Hypertension Completed Gilead Sciences Phase 3 The primary objective of this study was to evaluate the safety and efficacy of ambrisentan in a broad population of participants with pulmonary hypertension (PH). Secondary objectives of this study were to evaluate the effects of ambrisentan on other clinical measures of pulmonary arterial hypertension (PAH), long-term treatment success, and survival.
NCT00423202 A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Assess Safety and Efficacy of Ambrisentan in Subjects With Pulmonary Arterial Hypertension. Completed Gilead Sciences Phase 3 A phase 3, randomized, double-blind, placebo-controlled study to assess safety and efficacy of ambrisentan in subjects with pulmonary arterial hypertension.
NCT00423592 Phase 2 Study of Ambrisentan for Liver Function Test Rescue in Pulmonary Arterial Hypertension Completed Gilead Sciences Phase 2 This Phase 2 study was to determine the incidence of increased serum aminotransferase concentrations (alanine aminotransferase [ALT] and/or aspartate aminotransferase [AST]), as well as the overall safety and tolerability of ambrisentan, in participants with pulmonary arterial hypertension (PAH), idiopathic PAH (IPAH), or familial PAH (FPAH) who had previously discontinued ERA therapy (bosentan or sitaxsentan) due to increased serum ALT or AST concentrations.
NCT00423748 Study to Assess Safety and Efficacy of Ambrisentan in Subjects With Pulmonary Arterial Hypertension. Completed Gilead Sciences Phase 3 A phase 3, randomized, double-blind, placebo-controlled study to assess safety and efficacy of ambrisentan in subjects with pulmonary arterial hypertension.
NCT00424021 Phase 2 Extension Study of Ambrisentan in Pulmonary Arterial Hypertension Completed Gilead Sciences Phase 2 AMB-220-E is an international, multicenter, open-label study examining the long-term safety of ambrisentan (BSF 208075) in subjects who have previously completed Myogen study NCT00046319, "A Phase II, Randomized, Double-Blind, Dose-Controlled, Dose-Ranging, Multicenter Study of BSF 208075 Evaluating Exercise Capacity in Subjects with Moderate to Severe Pulmonary Arterial Hypertension".
NCT00540436 Evaluate the Efficacy, Safety and Pharmacokinetics of GSK1325760A in the Treatment of Pulmonary Arterial Hypertension Completed GlaxoSmithKline Phase 2 The primary objective of this study is to evaluate the effect of GSK1325760A on improvement in exercise capacity in subjects with pulmonary arterial hypertension (PAH). The secondary objectives of this study are to evaluate administration of GSK1325760A on: - The safety and tolerability - Improvement of PAH - The steady-state plasma pharmacokinetics of GSK1325760A
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Ambrisentan

Condition Name

Condition Name for Ambrisentan
Intervention Trials
Pulmonary Hypertension 14
Pulmonary Arterial Hypertension 14
Hypertension, Pulmonary 7
Systemic Sclerosis 4
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Condition MeSH

Condition MeSH for Ambrisentan
Intervention Trials
Hypertension 38
Hypertension, Pulmonary 26
Familial Primary Pulmonary Hypertension 23
Scleroderma, Diffuse 6
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Clinical Trial Locations for Ambrisentan

Trials by Country

Trials by Country for Ambrisentan
Location Trials
United States 226
Germany 41
Canada 30
Australia 22
Italy 21
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Trials by US State

Trials by US State for Ambrisentan
Location Trials
Massachusetts 14
California 13
North Carolina 11
Texas 11
Pennsylvania 10
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Clinical Trial Progress for Ambrisentan

Clinical Trial Phase

Clinical Trial Phase for Ambrisentan
Clinical Trial Phase Trials
Phase 4 9
Phase 3 14
Phase 2/Phase 3 2
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Clinical Trial Status

Clinical Trial Status for Ambrisentan
Clinical Trial Phase Trials
Completed 25
Recruiting 8
Active, not recruiting 5
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Clinical Trial Sponsors for Ambrisentan

Sponsor Name

Sponsor Name for Ambrisentan
Sponsor Trials
Gilead Sciences 22
GlaxoSmithKline 11
United Therapeutics 2
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Sponsor Type

Sponsor Type for Ambrisentan
Sponsor Trials
Other 70
Industry 39
NIH 4
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