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Generated: March 21, 2019

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CLINICAL TRIALS PROFILE FOR ALPROSTADIL

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Clinical Trials for Alprostadil

Trial ID Title Status Sponsor Phase Summary
NCT00248209 Female Orgasmic Disorder (FOD) and Wellbutrin XL Completed GlaxoSmithKline Phase 2/Phase 3 A recently completed multi-site double-blind placebo-controlled study found that bupropion (Wellbutrin XL) increased female orgasmic function in a group of pre-menopausal women with a diagnosis of hypoactive sexual desire disorder. The purpose of this study is to ascertain whether bupropion will improve orgasmic function in pre-menopausal women with a primary complaint of idiopathic orgasmic disorder who do not have hypoactive sexual desire disorder. This will be a multicenter, placebo-controlled, double blind study of women with a diagnosis of female orgasm disorder. During a baseline visit, psychiatric, medical, alcohol and drug, and sexual histories will be obtained. Patients who continue to meet screening inclusion/exclusion criteria at their baseline visit will be randomly assigned to either placebo or bupropion XL for 8 weeks. A flexible dosing paradigm will be used. Sexual desire and activity will be assessed by patient diaries, investigator interview of sexual functioning every two weeks, and by standardized questionnaire every four weeks. The primary endpoint will be the increase in orgasm completion as measured by the Changes in Sexual Functioning Questionnaire-F (CSFQ-F). Secondary endpoints will be changes in sexual arousal, sexual desire, and sexual pleasure as assessed by the CSFQ-F.
NCT00248209 Female Orgasmic Disorder (FOD) and Wellbutrin XL Completed Segraves, R., T., M.D., Ph.D. Phase 2/Phase 3 A recently completed multi-site double-blind placebo-controlled study found that bupropion (Wellbutrin XL) increased female orgasmic function in a group of pre-menopausal women with a diagnosis of hypoactive sexual desire disorder. The purpose of this study is to ascertain whether bupropion will improve orgasmic function in pre-menopausal women with a primary complaint of idiopathic orgasmic disorder who do not have hypoactive sexual desire disorder. This will be a multicenter, placebo-controlled, double blind study of women with a diagnosis of female orgasm disorder. During a baseline visit, psychiatric, medical, alcohol and drug, and sexual histories will be obtained. Patients who continue to meet screening inclusion/exclusion criteria at their baseline visit will be randomly assigned to either placebo or bupropion XL for 8 weeks. A flexible dosing paradigm will be used. Sexual desire and activity will be assessed by patient diaries, investigator interview of sexual functioning every two weeks, and by standardized questionnaire every four weeks. The primary endpoint will be the increase in orgasm completion as measured by the Changes in Sexual Functioning Questionnaire-F (CSFQ-F). Secondary endpoints will be changes in sexual arousal, sexual desire, and sexual pleasure as assessed by the CSFQ-F.
NCT00314548 Inhaled Prostacyclin for Adult Respiratory Distress Syndrome (ARDS) and Pulmonary Hypertension Completed Medical Research Council, Pakistan N/A Summary of the proposed research: The intravenous application of prostacyclin (PGE1) or its stable analogue, iloprost, has been used to cause a decrease not only of the pulmonary but also of the systemic vascular tone. Aerosolized prostacyclin, on the other hand, can result in a selective pulmonary vasodilatation without affecting the systemic blood pressure as shown in preliminary studies/case reports. No large trials exist for this type of use of the drug so far. Furthermore, aerosolized PGI2 can improve gas exchange and pulmonary shunt in clinical settings of impaired ventilation/perfusion ratio as it occurs in adult respiratory distress syndrome (ARDS) due to the redistribution of pulmonary blood flow from non-ventilated to ventilated, aerosol accessible lung regions. Therefore, the investigators propose to carry out a prospective, double blinded, randomized trial to show that the nebulized iloprost decreases pulmonary hypertension selectively and improves oxygenation in ARDS.
NCT00314548 Inhaled Prostacyclin for Adult Respiratory Distress Syndrome (ARDS) and Pulmonary Hypertension Completed Aga Khan University N/A Summary of the proposed research: The intravenous application of prostacyclin (PGE1) or its stable analogue, iloprost, has been used to cause a decrease not only of the pulmonary but also of the systemic vascular tone. Aerosolized prostacyclin, on the other hand, can result in a selective pulmonary vasodilatation without affecting the systemic blood pressure as shown in preliminary studies/case reports. No large trials exist for this type of use of the drug so far. Furthermore, aerosolized PGI2 can improve gas exchange and pulmonary shunt in clinical settings of impaired ventilation/perfusion ratio as it occurs in adult respiratory distress syndrome (ARDS) due to the redistribution of pulmonary blood flow from non-ventilated to ventilated, aerosol accessible lung regions. Therefore, the investigators propose to carry out a prospective, double blinded, randomized trial to show that the nebulized iloprost decreases pulmonary hypertension selectively and improves oxygenation in ARDS.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Alprostadil

Condition Name

Condition Name for Alprostadil
Intervention Trials
Erectile Dysfunction 4
Drug-induced Liver Injury,Chronic 2
ST Segment Elevation Myocardial Infarction 2
Pulmonary Hypertension 2
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Condition MeSH

Condition MeSH for Alprostadil
Intervention Trials
Erectile Dysfunction 6
Respiratory Distress Syndrome, Newborn 3
Respiratory Distress Syndrome, Adult 3
Sexual Dysfunctions, Psychological 3
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Clinical Trial Locations for Alprostadil

Trials by Country

Trials by Country for Alprostadil
Location Trials
United States 20
China 9
Germany 2
Austria 2
Russian Federation 1
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Trials by US State

Trials by US State for Alprostadil
Location Trials
California 5
Ohio 4
Michigan 2
Pennsylvania 1
New York 1
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Clinical Trial Progress for Alprostadil

Clinical Trial Phase

Clinical Trial Phase for Alprostadil
Clinical Trial Phase Trials
Phase 4 8
Phase 3 2
Phase 2/Phase 3 1
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Clinical Trial Status

Clinical Trial Status for Alprostadil
Clinical Trial Phase Trials
Completed 10
Not yet recruiting 4
Recruiting 4
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Clinical Trial Sponsors for Alprostadil

Sponsor Name

Sponsor Name for Alprostadil
Sponsor Trials
Beijing 302 Hospital 3
Shanghai 10th People's Hospital 2
RenJi Hospital 2
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Sponsor Type

Sponsor Type for Alprostadil
Sponsor Trials
Other 25
Industry 11
NIH 1
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