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Generated: December 10, 2018

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CLINICAL TRIALS PROFILE FOR ALFENTANIL HYDROCHLORIDE

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Clinical Trials for Alfentanil Hydrochloride

Trial ID Title Status Sponsor Phase Summary
NCT00001307 Positron Emission Tomography to Measure Pain and Pain Control Completed National Institute of Dental and Craniofacial Research (NIDCR) N/A This study will examine how the brain processes pain signals and how the different parts of the brain work with each other in response to painful stimuli. A better understanding of how people experience pain may be helpful in developing more effective treatments. Healthy normal volunteers, patients requiring third molar (wisdom tooth) extraction, and patients with persistent pain due to disease, injury or other reason may be eligible for this study. Participants will receive one or more of the following sensory stimuli, which may cause brief discomfort or pain: - Heat/Cold - applied by an electronically controlled device that touches the skin, or by temperature-controlled water baths, or by a thermally controlled brass cylinder the subject grasps - Capsaicin (active ingredient in hot chili peppers) - injected in a small volume of fluid under the skin or into a muscle - Mechanical stimulation - brushings or vibrations that do not normally cause pain - Ischemic stimulation - inflation of a blood pressure cuff on the arm or leg for up to 30 minutes These stimuli will be applied both before and during positron emission tomography (PET) scanning. This test shows which parts of the brain are active and which are not and is important for studying how different parts of the brain work together to feel and react to specific sensations. For this procedure, the subject lies on a table in the PET scanner while a series of scans are taken during different sensory conditions. At the beginning of each scan, radioactive water is injected into an arm vein through a catheter (a thin plastic tube). A special camera records the arrival and disappearance of the radiation in various brain areas, creating a picture of the brain's activity in various regions. Oral surgery patients may have PET scans both before and after their wisdom tooth extraction. Alfentanil, a commonly used narcotic pain reliever, will also be given during the PET procedure to determine how the brain responds to sensory stimuli while under the effects of a pain killer. Participants will also have a magnetic resonance imaging (MRI) scan of the brain to help interpret the PET results. MRI uses a magnetic field and radio waves to show structural and chemical changes in tissues. During the scan, the subject lies on a table in a cylindrical machine (the scanner). He or she can speak with a staff member via an intercom system. Some sensory studies may require placing an arterial and/or intravenous line. Following injection of a local anesthetic, a catheter is placed in an artery in the arm. At regular intervals during various sensory stimuli, small blood samples are drawn from the artery to measure blood gases and other substances. Samples may also be drawn from a catheter placed in a vein. Subjects may also have ultrasound monitoring to evaluate blood flow in the arteries, veins and brain. A gel is spread over the skin above the blood vessel and a hand-foot-and-mouth device is placed on the gel. The device emits high-frequency sound waves to produce a picture of the speed of blood flow in the artery and the diameter of the vessel.
NCT00226564 Genetic Determinants of Opioids Analgesia Completed Hadassah Medical Organization N/A The response to opioids varies greatly among individuals. Some of these variability is accounted for by genetic factors. The present study was designed to evaluate the possibility that genetic polymorphism in the gene encoding for mu opioid receptor may explain variability in the response to alfentanil during lithotripsy.
NCT00440960 Anesthesia in Flexible Bronchoscopy for Lung Cancer Diagnostic Completed Hospital Pompeia Phase 4 The objective of the study was to establish which anesthetic procedure used during flexible bronchoscopy has the lowest index of complications.
NCT00478907 Prevention of Complications of Eye Surgery Completed Isfahan University of Medical Sciences Phase 2 This study was designed to investigate pre-operatively measured parameters of various anaesthetic regimes, iris color, sex, age, surgical time, severity of Marcus-Gunn Pupil (MGP), type of mechanical stimulation of eye, and number of extraocular muscle (EOM) under tension as predictors of significant OCR in pediatric strabismus surgery.
NCT00742807 Pain Evaluation During Follicle Aspiration: Comparison of Two Sedation Protocols Unknown status University Hospital, Ghent Phase 4 Giving infiltration analgesia around the neck of the womb (= paracervical block, PCB) is frequently experienced as a painful procedure by women undergoing follicle aspiration. Two sedation protocols, where in the one protocol a low dose of alfentanil hydrochloride is already administered before the PCB, will be compared with each other and pain relief measured using the 'Visual Analogue Scale' and the 'Short-Form McGill Questionnaire'
NCT00789815 Bispectral Index-guided Sedation for Flexible Bronchoscopy Completed Chang Gung Memorial Hospital Phase 4 With the advances of flexible bronchoscopy, like metallic stent, electrocautery and real time endobronchial ultrasound, the complexity and duration of procedures are increasing. So, adequate sedation and analgesia is important for both patients and bronchoscopist. Clinical-judged midazolam administration is the current standard. However, midazolam is difficult to titrated and the clinical observations are not reliable sedative indices. Propofol is titrated easily because of its unique pharmacokinetics. Bispectral index (BIS), a real time monitor of depth-of-sedation, has been applied in general anesthesia. We design a BIS-guided propofol sedation for bronchoscopy. Through the combination of advantages of propofol and BIS, we hope to provide patients a more tolerable and safety sedation for bronchoscopy.
NCT00991809 Study on the Development of Opioid Induced Hyperalgesia (OIH) After Exposure to Alfentanil Completed National Institute on Drug Abuse (NIDA) N/A The purpose of this study is to follow a person's response to experimental pain after multiple consecutive exposures to alfentanil or diphenhydramine to see if the person can tolerate the pain more, less, or the same at the end of the study.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Alfentanil Hydrochloride

Condition Name

Condition Name for Alfentanil Hydrochloride
Intervention Trials
Pain 5
Sedation 3
Lung Disease 2
Hyperalgesia 2
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Condition MeSH

Condition MeSH for Alfentanil Hydrochloride
Intervention Trials
Lung Diseases 2
Hyperalgesia 2
Gastrointestinal Diseases 2
Digestive System Diseases 2
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Clinical Trial Locations for Alfentanil Hydrochloride

Trials by Country

Trials by Country for Alfentanil Hydrochloride
Location Trials
United States 7
Israel 4
Norway 3
Turkey 2
Taiwan 2
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Trials by US State

Trials by US State for Alfentanil Hydrochloride
Location Trials
Minnesota 2
Maryland 2
North Carolina 1
California 1
Missouri 1
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Clinical Trial Progress for Alfentanil Hydrochloride

Clinical Trial Phase

Clinical Trial Phase for Alfentanil Hydrochloride
Clinical Trial Phase Trials
Phase 4 14
Phase 3 3
Phase 2 1
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Clinical Trial Status

Clinical Trial Status for Alfentanil Hydrochloride
Clinical Trial Phase Trials
Completed 25
Unknown status 5
Not yet recruiting 3
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Clinical Trial Sponsors for Alfentanil Hydrochloride

Sponsor Name

Sponsor Name for Alfentanil Hydrochloride
Sponsor Trials
Rabin Medical Center 2
Oslo University Hospital 2
Minneapolis Medical Research Foundation 2
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Sponsor Type

Sponsor Type for Alfentanil Hydrochloride
Sponsor Trials
Other 38
NIH 2
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