You're using a free limited version of DrugPatentWatch: Upgrade for Complete Access

Last Updated: December 12, 2024

CLINICAL TRIALS PROFILE FOR AFAMELANOTIDE


✉ Email this page to a colleague

« Back to Dashboard


All Clinical Trials for Afamelanotide

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00472901 ↗ Phase III Trial of CUV1647 in Polymorphic Light Eruption (PLE) Completed Clinuvel Pharmaceuticals Limited 2007-05-01 The purpose of this study is to determine whether the afamelanotide (CUV1647) formulation is effective in preventing PLE episodes or reducing the severity of PLE symptoms in patients with a well documented history of the disease. The study also aims to determine whether treatment with afamelanotide (CUV1647) can reduce the use of rescue medication in this group.
NCT00829192 ↗ Phase II AK Study in Organ Transplant Patients Unknown status Clinuvel Pharmaceuticals Limited Phase 2 2007-11-01 The purpose of this study is to determine whether afamelanotide (CUV1647) is effective in reducing the number of actinic keratoses and squamous cell carcinomas developing in immune compromised organ transplant recipients, who are at particularly high risk, over a 24 month test period. The number of lesions formed on the head, hands and forarms will be monitored over this 24 month test period.
NCT00859534 ↗ Phase II Solar Urticaria (SU) Pilot Study Completed Clinuvel Pharmaceuticals Limited Phase 2 2008-12-01 Urticaria is one of the most common dermatological conditions with diverse clinical presentations and causes. Solar urticaria (SU) is a rare subset of physical urticaria, where symptoms are induced by direct exposure of the skin to sunlight. As little as 5 minutes of sun exposure can cause flares and whealing on exposed skin sites, accompanied by severe itching. The wavelengths of radiation causing the eruption (i.e. the action spectrum) are in the ultraviolet or visible light range. Initially described by Merklen in 1904, SU may have a very sudden and dramatic onset, and then rapidly disappear once the exposure ceases. A delayed form of SU has also been reported, although this is extremely rare. Information on the pathophysiology of SU is limited and symptoms are confined to areas of the body exposed to direct sunlight. The condition can be very distressing and severely impair the individual's ability to go outdoors and to tolerate indoor lighting. The standard therapy, i.e. oral antihistamines, is only partially effective and may provide little worthwhile relief of symptoms. This pilot study is proposed to evaluate implants containing 16mg CUV1647 as a prophylactic treatment for patients with SU. The effectiveness of CUV1647 will be assessed by determining the minimum urticarial dose before and after treatment.
NCT00979745 ↗ Phase III Confirmatory Study in Erythropoietic Protoporphyria (EPP) Completed Clinuvel Pharmaceuticals Limited Phase 3 2009-09-01 Afamelanotide is a man-made drug being studied for use as a preventative medication for EPP sufferers. It is a synthetically produced analogue of human alpha melanocyte stimulating hormone (alpha-MSH) and is not yet available on the market. The purpose of this study is to look at whether afamelanotide can reduce the number and severity of EPP symptoms when patients are exposed to light. This study will also look at how the drug is tolerated when taken by people with EPP. The study will involve the use of an implant, which comes in the form of a small rod (approximately 2 cm x 0.15 cm) to be administered under the skin. The implant may contain the study drug afamelanotide or a placebo (inactive medication). Over 450 subjects have been treated with afamelanotide to date with no serious safety concerns identified. For this study, afamelanotide has been formulated as a controlled release depot injection (implant). This means that the afamelanotide will be released slowly into the body over a few days. Once inserted, the implant will remain in the body after afamelanotide has been released and will slowly dissolve. This study will help to provide more information about afamelanotide. This information will be used to determine the safety and efficacy (the ability of the drug to produce an effect) of this drug in EPP sufferers. Up to 70 people will participate in this study from study sites across Europe.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Afamelanotide

Condition Name

Condition Name for Afamelanotide
Intervention Trials
Vitiligo 5
Erythropoietic Protoporphyria 5
Xeroderma Pigmentosum 2
Polymorphic Light Eruption (PLE) 1
[disabled in preview] 0
This preview shows a limited data set
Subscribe for full access, or try a Trial

Condition MeSH

Condition MeSH for Afamelanotide
Intervention Trials
Protoporphyria, Erythropoietic 5
Vitiligo 5
Ichthyosis 2
Dermatitis, Contact 2
[disabled in preview] 0
This preview shows a limited data set
Subscribe for full access, or try a Trial

Clinical Trial Locations for Afamelanotide

Trials by Country

Trials by Country for Afamelanotide
Location Trials
United States 17
Australia 5
United Kingdom 5
Germany 3
Netherlands 2
This preview shows a limited data set
Subscribe for full access, or try a Trial

Trials by US State

Trials by US State for Afamelanotide
Location Trials
California 3
New York 3
Alabama 2
Michigan 2
Utah 2
This preview shows a limited data set
Subscribe for full access, or try a Trial

Clinical Trial Progress for Afamelanotide

Clinical Trial Phase

Clinical Trial Phase for Afamelanotide
Clinical Trial Phase Trials
Phase 3 6
Phase 2 12
Phase 1 3
[disabled in preview] 0
This preview shows a limited data set
Subscribe for full access, or try a Trial

Clinical Trial Status

Clinical Trial Status for Afamelanotide
Clinical Trial Phase Trials
Completed 14
Recruiting 6
Not yet recruiting 1
[disabled in preview] 1
This preview shows a limited data set
Subscribe for full access, or try a Trial

Clinical Trial Sponsors for Afamelanotide

Sponsor Name

Sponsor Name for Afamelanotide
Sponsor Trials
Clinuvel Pharmaceuticals Limited 16
Clinuvel Europe Limited 2
Clinuvel, Inc. 2
[disabled in preview] 2
This preview shows a limited data set
Subscribe for full access, or try a Trial

Sponsor Type

Sponsor Type for Afamelanotide
Sponsor Trials
Industry 22
[disabled in preview] 0
This preview shows a limited data set
Subscribe for full access, or try a Trial

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.