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Generated: December 15, 2018

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CLINICAL TRIALS PROFILE FOR ACTHAR

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Clinical Trials for Acthar

Trial ID Title Status Sponsor Phase Summary
NCT00805753 Dose-Finding Pilot Study of ACTH in Patients With Idiopathic Membranous Nephropathy Completed Mallinckrodt Phase 1 This pilot study is aimed at demonstrating the effectiveness of ACTH (H.P. Acthar Gel) on the lipid profile and proteinuria in participants with MN. ACTH or adrenocorticotrophin is a hormone produced by the pituitary gland (a gland at the base of your brain) that is involved in stimulating your adrenal glands to secrete a number of steroid products (e.g. cortisol, aldosterone, corticosterone, and others) that are important in keeping you alive. The drug used in this study has been approved by the Food and Drug Administration (FDA) for routine clinical use in the treatment of patients with proteinuria and patients with idiopathic nephrotic syndrome such as idiopathic MN. However, the most adequate dose to use has not been adequately assessed. This is the reason for conducting this research study.
NCT00805753 Dose-Finding Pilot Study of ACTH in Patients With Idiopathic Membranous Nephropathy Completed Mayo Clinic Phase 1 This pilot study is aimed at demonstrating the effectiveness of ACTH (H.P. Acthar Gel) on the lipid profile and proteinuria in participants with MN. ACTH or adrenocorticotrophin is a hormone produced by the pituitary gland (a gland at the base of your brain) that is involved in stimulating your adrenal glands to secrete a number of steroid products (e.g. cortisol, aldosterone, corticosterone, and others) that are important in keeping you alive. The drug used in this study has been approved by the Food and Drug Administration (FDA) for routine clinical use in the treatment of patients with proteinuria and patients with idiopathic nephrotic syndrome such as idiopathic MN. However, the most adequate dose to use has not been adequately assessed. This is the reason for conducting this research study.
NCT00854750 Modeling and Treating the Pathophysiology of Demyelination in Multiple Sclerosis Terminated Mallinckrodt Phase 4 The investigators principal hypothesis is that INO and optic neuritis are objective, quantitative, and reproducible models for corroborating the hypothesis that changes in core body temperature are associated with the reversible and stereotypic decay in axonal conduction and that ACTHAR can serve to prevent such changes. The application of ocular motor and optic nerve measures appears to constitute a useful paradigm to detect and monitor responses to therapeutic strategies that stabilize nerve cell membranes in response to temperature induced decay in axonal conduction mechanisms, with implications on activities of daily life that are dependent upon vision (reading, driving, walking, work performance).
NCT00854750 Modeling and Treating the Pathophysiology of Demyelination in Multiple Sclerosis Terminated Elliot Frohman Phase 4 The investigators principal hypothesis is that INO and optic neuritis are objective, quantitative, and reproducible models for corroborating the hypothesis that changes in core body temperature are associated with the reversible and stereotypic decay in axonal conduction and that ACTHAR can serve to prevent such changes. The application of ocular motor and optic nerve measures appears to constitute a useful paradigm to detect and monitor responses to therapeutic strategies that stabilize nerve cell membranes in response to temperature induced decay in axonal conduction mechanisms, with implications on activities of daily life that are dependent upon vision (reading, driving, walking, work performance).
NCT01021540 Prospective Study Evaluating the Effect of Repository Corticotropin in the Treatment of Various Nephrotic Syndromes Completed Arizona Kidney Disease and Hypertension Center Phase 4 To determine if H.P. Acthar Gel (repository corticotrophin) has the same anti-proteinuric effects seen with the synthetic ACTH analogue in Europe.
NCT01028287 Adrenocorticotropic Hormone (ACTH) Treatment of Nephrotic Range Proteinuria in Diabetic Nephropathy (NRDN) Completed Mallinckrodt Phase 4 This is a prospective open labeled trial examining the efficacy of ACTHar Gel (porcine ACTH) on the level of proteinuria in patients with diabetic nephropathy and nephrotic range proteinuria.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Acthar

Condition Name

Condition Name for Acthar
Intervention Trials
Multiple Sclerosis 8
Sarcoidosis 5
Rheumatoid Arthritis 4
Proteinuria 4
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Condition MeSH

Condition MeSH for Acthar
Intervention Trials
Sclerosis 14
Multiple Sclerosis 14
Kidney Diseases 9
Sarcoidosis 8
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Clinical Trial Locations for Acthar

Trials by Country

Trials by Country for Acthar
Location Trials
United States 133
Canada 3
Chile 2
Turkey 1
Mexico 1
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Trials by US State

Trials by US State for Acthar
Location Trials
New York 17
California 14
Florida 11
Texas 10
Tennessee 8
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Clinical Trial Progress for Acthar

Clinical Trial Phase

Clinical Trial Phase for Acthar
Clinical Trial Phase Trials
Phase 4 38
Phase 3 5
Phase 2/Phase 3 2
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Clinical Trial Status

Clinical Trial Status for Acthar
Clinical Trial Phase Trials
Recruiting 24
Not yet recruiting 20
Unknown status 10
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Clinical Trial Sponsors for Acthar

Sponsor Name

Sponsor Name for Acthar
Sponsor Trials
Mallinckrodt 50
The Cleveland Clinic 3
Columbia University 2
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Sponsor Type

Sponsor Type for Acthar
Sponsor Trials
Other 70
Industry 51
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Serving hundreds of leading biopharmaceutical companies globally:

US Department of Justice
Queensland Health
Merck
Federal Trade Commission
Healthtrust
Argus Health
Chinese Patent Office
Cipla
Dow

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