You're using a free limited version of DrugPatentWatch: Upgrade for Complete Access

Last Updated: February 7, 2025

CLINICAL TRIALS PROFILE FOR ACETATED RINGER'S IN PLASTIC CONTAINER


✉ Email this page to a colleague

« Back to Dashboard


All Clinical Trials for Acetated Ringer's In Plastic Container

Trial ID Title Status Sponsor Phase Start Date Summary
NCT01250886 ↗ Acid-base Balance in Patients Undergoing Colonoscopy Unknown status Mahidol University Phase 1 2010-12-01 The purpose of this study is to determine whether fluid administration in patients undergoing colonoscopy should affect acid-base disorder in term of the strong ion differences.
NCT01438502 ↗ "The Effect of Reduced Fluid Load After Cardiac Surgery" Withdrawn Haukeland University Hospital 1969-12-31 The purpose of this study is to verify that an infusion of hypertonic saline/colloids during cardio-pulmonary-bypass will reduce fluid overload and organ edema for cardiac patients with expected long-CPB-time. Expected beneficial effects are improved organ function for heart and lungs.
NCT01511120 ↗ The Effect on Fluid Balance After Cardiac Surgery After Use of Two Different Priming Protocols Completed Haukeland University Hospital Phase 2 2011-11-01 "The impact on fluid loading after cardiac surgery by use of two different priming solution" Fluid overloading with oedema formation is a regular finding following on-pump cardiac surgery and may contribute to postoperative organ dysfunction. Myocardial oedema has been reported to impair both systolic and diastolic function. An association between intraoperative fluid loading and postoperative adverse outcome has been demonstrated in cardiac patients. The investigators have experience with the use of both colloides and combination fluids (hypertonic saline/colloides) in several experimental studies (pigs). In one animal study the investigators used colloides as an additive to the CPB-prime. The investigators observed reduced fluid leakage and less total tissue water in several organs. The planned study includes patients scheduled for coronary artery bypass, and who have no co-morbidity. The patients will be randomized to receive either Tetraspan® (HES) or acetated Ringer's solution in the CPB-prime. Accurate accounts of fluid additions, blood loss and diuresis will be kept. Determination of cardiac output (C.O.), intrathoracic blood volume (ITBV), extravascular lung water (EVLW) and global end diastolic volume (GEDV) will be monitored by use of the transpulmonary thermodilution technique PiCCO®plus system.
NCT02079064 ↗ Effects of Desflurane Versus Propofol on Hemostasis During Splenectomy Completed Theodor Bilharz Research Institute N/A 2014-01-01 The aim of this prospective randomized study is to evaluate the perioperative effects of inhalational anesthesia (desflurane) and intravenous anesthesia (propofol) on hemostasis in patients undergoing splenectomy with liver cirrhosis guided by the new technology (ROTEM) and the traditional laboratory hemostatic markers.
NCT03685214 ↗ Comparison of Balanced Crystalloids and Normal Saline in Septic Patients Unknown status Wu Jieping Medical Foundation N/A 2019-03-01 In this prospective randomized controlled trial, investigators attempt to study the effects of acetated Ringer's solution on the prognosis and renal function of patients with sepsis in intensive care unit compared with normal saline, and provide evidence for current fluid resuscitation strategies for sepsis.
NCT03685214 ↗ Comparison of Balanced Crystalloids and Normal Saline in Septic Patients Unknown status ZhiYong Peng N/A 2019-03-01 In this prospective randomized controlled trial, investigators attempt to study the effects of acetated Ringer's solution on the prognosis and renal function of patients with sepsis in intensive care unit compared with normal saline, and provide evidence for current fluid resuscitation strategies for sepsis.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Acetated Ringer's In Plastic Container

Condition Name

Condition Name for Acetated Ringer's In Plastic Container
Intervention Trials
Hypovolemia 1
Organ Edema 1
Organ Function 1
Sepsis 1
[disabled in preview] 0
This preview shows a limited data set
Subscribe for full access, or try a Trial

Condition MeSH

Condition MeSH for Acetated Ringer's In Plastic Container
Intervention Trials
Shock, Septic 2
Toxemia 1
Coronary Artery Disease 1
Sepsis 1
[disabled in preview] 0
This preview shows a limited data set
Subscribe for full access, or try a Trial

Clinical Trial Locations for Acetated Ringer's In Plastic Container

Trials by Country

Trials by Country for Acetated Ringer's In Plastic Container
Location Trials
Norway 2
China 1
Egypt 1
This preview shows a limited data set
Subscribe for full access, or try a Trial

Clinical Trial Progress for Acetated Ringer's In Plastic Container

Clinical Trial Phase

Clinical Trial Phase for Acetated Ringer's In Plastic Container
Clinical Trial Phase Trials
Phase 4 1
Phase 2 1
Phase 1 1
[disabled in preview] 3
This preview shows a limited data set
Subscribe for full access, or try a Trial

Clinical Trial Status

Clinical Trial Status for Acetated Ringer's In Plastic Container
Clinical Trial Phase Trials
Completed 2
Not yet recruiting 2
Unknown status 2
[disabled in preview] 1
This preview shows a limited data set
Subscribe for full access, or try a Trial

Clinical Trial Sponsors for Acetated Ringer's In Plastic Container

Sponsor Name

Sponsor Name for Acetated Ringer's In Plastic Container
Sponsor Trials
Haukeland University Hospital 2
Mahidol University 1
Theodor Bilharz Research Institute 1
[disabled in preview] 3
This preview shows a limited data set
Subscribe for full access, or try a Trial

Sponsor Type

Sponsor Type for Acetated Ringer's In Plastic Container
Sponsor Trials
Other 9
[disabled in preview] 0
This preview shows a limited data set
Subscribe for full access, or try a Trial

Acetated Ringer's Injection in Plastic Containers: Clinical Trials, Market Analysis, and Projections

Introduction

Acetated Ringer's injection, also known as Ringer's acetate or Hartmann's solution, is a crucial intravenous fluid used for fluid resuscitation, maintenance of hydration, and correction of electrolyte imbalances. This article delves into the clinical aspects, market analysis, and future projections of acetated Ringer's injection in plastic containers.

Clinical Use and Indications

Acetated Ringer's injection is a sterile, nonpyrogenic solution that serves as a source of water and electrolytes. It is indicated for fluid and electrolyte replenishment and is commonly used in hospital settings, particularly in critical care, surgery, and emergency departments[2][4].

Composition and Safety

The solution contains sodium chloride, potassium chloride, and calcium chloride, along with sodium acetate, which helps in maintaining the pH balance. The safety of the plastic containers, typically made from polyvinyl chloride (PL 146 Plastic), has been confirmed through USP biological tests and tissue culture toxicity studies[1][4].

Contraindications and Precautions

Acetated Ringer's injection is contraindicated in patients with known hypersensitivity to the product or its ingredients. It is also contraindicated in newborns receiving concomitant treatment with ceftriaxone. Special precautions are necessary for pediatric and geriatric patients due to potential electrolyte imbalances and the maturation status of their organs[1][4].

Market Analysis

Market Size and Growth

The global compound sodium acetate ringer injection market was estimated to be around USD 1.4 billion in 2023 and is projected to reach approximately USD 2.4 billion by 2033, growing at a compound annual growth rate (CAGR) of 5.2% from 2024 to 2033[2].

Regional Market

North America dominates the market, accounting for a significant revenue share, followed by Europe and the Asia-Pacific region. The United States is a major contributor to the North American market due to its high prevalence of chronic diseases and well-established healthcare infrastructure. The Asia-Pacific region is expected to witness the highest growth rate during the forecast period, driven by improving healthcare infrastructure and rising healthcare awareness[2].

End User Segment

The hospital segment holds the largest market share, driven by the high consumption of acetated Ringer's injection in hospital settings for fluid management. The 1000 mL packaging segment is expected to witness the highest growth rate due to its widespread use in fluid resuscitation and maintenance therapy[2].

Packaging and Delivery Systems

The packaging of acetated Ringer's injection plays a critical role in its market dynamics. The 500 mL packaging segment currently dominates the market, but the 1000 mL segment is expected to grow significantly due to its preference in fluid resuscitation for critically ill patients and major surgeries[2].

Innovations in Packaging

The development of novel packaging and delivery systems, such as ready-to-use bags and pre-mixed solutions, is expected to enhance the convenience and safety of administration. These innovations could drive market growth by improving patient-centered care and individualized fluid therapy[2].

Clinical Trials and Regulatory Aspects

While specific clinical trials for acetated Ringer's injection may not be extensively detailed, the safety and efficacy of these solutions are well-established through various medical literature and regulatory approvals. Manufacturers must comply with complex guidelines set by regulatory bodies like the U.S. FDA and EMA, which involves extensive clinical testing and documentation[5].

Regulatory Compliance

Obtaining regulatory clearance for acetated Ringer's injection involves rigorous testing, including USP biological tests for plastic containers and tissue culture toxicity studies. Any changes to approved formulations or manufacturing sites require prior regulatory approval, making the process lengthy and costly[1][5].

Market Opportunities and Challenges

Growing Demand in Emerging Markets

The growing healthcare infrastructure in emerging economies presents significant opportunities for acetated Ringer's injection suppliers. Countries like India, China, and Brazil are increasing their healthcare spending, generating substantial demand for intravenous fluids[2][5].

Challenges

Despite the growth opportunities, the market faces challenges such as the availability of alternative IV fluids, the potential for adverse reactions, and the need for proper storage and handling of the product. These factors necessitate continuous innovation and adherence to stringent regulatory norms[2].

Future Outlook

Market Growth Drivers

The market is expected to benefit from the rising prevalence of chronic diseases, the growing number of surgical procedures, and the expanding healthcare infrastructure in emerging markets. The increasing focus on patient-centered care and the need for individualized fluid therapy will also shape the future of the market[2].

Technological Advancements

The integration of technologies like artificial intelligence (AI) and machine learning can optimize production processes and improve inventory management. Smart sensors in infusion systems can provide real-time data to healthcare professionals, enhancing the safety and efficacy of acetated Ringer's injection administration[5].

Key Takeaways

  • Market Growth: The global compound sodium acetate ringer injection market is projected to grow at a CAGR of 5.2% from 2024 to 2033.
  • Regional Dominance: North America currently dominates the market, with the Asia-Pacific region expected to witness the highest growth rate.
  • Packaging Trends: The 1000 mL packaging segment is expected to grow significantly due to its use in fluid resuscitation and maintenance therapy.
  • Regulatory Compliance: Manufacturers must adhere to stringent regulatory norms, including extensive clinical testing and documentation.
  • Emerging Markets: Growing healthcare infrastructure in emerging economies presents significant growth opportunities.

FAQs

What is the primary use of acetated Ringer's injection?

Acetated Ringer's injection is primarily used for fluid resuscitation, maintenance of hydration, and correction of electrolyte imbalances.

Which region dominates the market for acetated Ringer's injection?

North America currently dominates the market, with the United States being a major contributor.

What are the key factors driving the growth of the acetated Ringer's injection market?

The growth is driven by the increasing demand for IV fluid therapy, the rising prevalence of chronic diseases, and the growing number of surgical procedures.

What are the challenges faced by the acetated Ringer's injection market?

The market faces challenges such as the availability of alternative IV fluids, potential adverse reactions, and the need for proper storage and handling.

How is the packaging of acetated Ringer's injection evolving?

The packaging is evolving with the development of novel systems like ready-to-use bags and pre-mixed solutions, enhancing convenience and safety.

Sources

  1. Ringer's Injection, USP - FDA Label[1]
  2. Compound Sodium Acetate Ringer Injection Market - Data Horizzon Research[2]
  3. Lactated Ringer's Injection, USP - FDA Label[3]
  4. Ringer's Injection, USP in VIAFLEX Plastic Container - FDA Label[4]
  5. Lactated Ringers Injection Market - Coherent Market Insights[5]

More… ↓

⤷  Free Trial

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.