CLINICAL TRIALS PROFILE FOR AVINZA

All Clinical Trials for AVINZA

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT00488969 ↗	Effectiveness of Controlled-Release Morphine for Chronic Neuropathic Pain After Spinal Cord Injury	Completed	U.S. Department of Education	Phase 2	2007-07-01	We would like to learn if a medicine called "modified-release morphine sulfate" (Avinza) helps reduce Spinal Cord Injury (SCI)-related pain that has lasted a long time. "Modified-release" means that the medicine in the capsules is slowly released to the body, instead of being released all at once. Avinza is approved by the Food and Drug Administration for the treatment of pain, but we do not know how effective Avinza is in reducing SCI-related pain.
NCT00488969 ↗	Effectiveness of Controlled-Release Morphine for Chronic Neuropathic Pain After Spinal Cord Injury	Completed	Icahn School of Medicine at Mount Sinai	Phase 2	2007-07-01	We would like to learn if a medicine called "modified-release morphine sulfate" (Avinza) helps reduce Spinal Cord Injury (SCI)-related pain that has lasted a long time. "Modified-release" means that the medicine in the capsules is slowly released to the body, instead of being released all at once. Avinza is approved by the Food and Drug Administration for the treatment of pain, but we do not know how effective Avinza is in reducing SCI-related pain.
NCT00640042 ↗	Evaluation of Risk Minimization, Assessment and Outcomes in Patients With Chronic Pain Taking Avinza	Completed	Pfizer	Phase 4	2008-03-01	The purpose of this study is to provide information in a broad, "real world" population of chronic pain patients assessing both pain control with AVINZA as well as the potential risk for misuse and abuse.
NCT00782548 ↗	Comparative Study to Evaluate KADIAN and Avinza in Healthy Adults	Completed	Actavis Inc.	Phase 4	2004-05-01	The primary objective of this study was to compare the single-dose relative bioavailability of Alpharma Branded Products Division (Kadian®) and Ligand® Pharmaceuticals Inc. (AVINZA®) 30 mg morphine sulfate sustained-release capsules in healthy adult volunteers under fed conditions. The secondary objective of this study was to evaluate the adverse events associated with each of these 2 different morphine sulfate modified-release commercial formulations
NCT00782548 ↗	Comparative Study to Evaluate KADIAN and Avinza in Healthy Adults	Completed	Alpharma Pharmaceuticals LLC, a subsidiary of Pfizer Inc.	Phase 4	2004-05-01	The primary objective of this study was to compare the single-dose relative bioavailability of Alpharma Branded Products Division (Kadian®) and Ligand® Pharmaceuticals Inc. (AVINZA®) 30 mg morphine sulfate sustained-release capsules in healthy adult volunteers under fed conditions. The secondary objective of this study was to evaluate the adverse events associated with each of these 2 different morphine sulfate modified-release commercial formulations
NCT00994383 ↗	Comparative Bioavailability Study of Morphine Sulfate Immediate Release and Controlled Release	Completed	Roxane Laboratories	N/A	2007-01-01	Characterize the steady-state pharmacokinetics of morphine after oral administration of Roxane Laboratories' morphine sulfate immediate release tablets and oral solution and to compare their pharmacokinetics to that of AVINZA.
NCT01538745 ↗	Low Dose Ketamine (LDK) Versus Morphine for Acute Pain Control in the Emergency Department	Completed	U.S. Air Force Office of the Surgeon General	Phase 4	2012-02-01	The purpose of this study is to compare the safety and effectiveness of intravenous low dose ketamine (LDK) to the industry standard of morphine (MOR) in regards to controlling acute pain in the emergency department. Both LDK and morphine have side effects. The amount and character of these side effects will be compared. Additionally, the degree of sedation or agitation will be specifically measured. The aim of this current study is to make this comparison and shift the evidence for LDK use from the anecdotal to the scientific.

Clinical Trial Conditions for AVINZA

Condition Name

Condition Name for AVINZA
Intervention	Trials
Pain	3
Back Pain	1
Metastatic Malignant Solid Neoplasm	1
Back Pain, Acute	1

Condition MeSH

Condition MeSH for AVINZA
Intervention	Trials
Flank Pain	1
Spinal Cord Injuries	1
Emergencies	1
Neoplasms, Second Primary	1

Clinical Trial Locations for AVINZA

Trials by Country

Trials by Country for AVINZA
Location	Trials
United States	40
Puerto Rico	1

Trials by US State

Trials by US State for AVINZA
Location	Trials
Texas	4
New York	2
South Carolina	1
Pennsylvania	1
Oregon	1

Clinical Trial Progress for AVINZA

Clinical Trial Phase

Clinical Trial Phase for AVINZA
Clinical Trial Phase	Trials
Phase 4	3
Phase 2/Phase 3	1
Phase 2	1

Clinical Trial Status

Clinical Trial Status for AVINZA
Clinical Trial Phase	Trials
Completed	6
Active, not recruiting	1

Clinical Trial Sponsors for AVINZA

Sponsor Name

Sponsor Name for AVINZA
Sponsor	Trials
Isfahan University of Medical Sciences	1
National Cancer Institute (NCI)	1
M.D. Anderson Cancer Center	1

Sponsor Type

Sponsor Type for AVINZA
Sponsor	Trials
Industry	4
U.S. Fed	3
Other	3