Last Updated: May 20, 2026

Biologic Drugs With Physiological Effect: Increased Coagulation Factor Activity

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Biologic Drugs With Physiological Effect: Increased Coagulation Factor Activity

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Patent Expiration
Baxter Healthcare Corporation	TISSEEL	fibrin sealant (tisseel)	For Injection	103980	2000-02-07	⤷ Start Trial	⤷ Start Trial
Omrix Biopharmaceuticals Ltd	EVITHROM	thrombin, topical (human)	Solution	125247	2007-08-27	⤷ Start Trial	⤷ Start Trial
Baxter Healthcare Corporation	ARTISS	fibrin sealant (human)	Frozen	125266	2008-03-19	⤷ Start Trial	⤷ Start Trial
Takeda Pharma A/s	TACHOSIL	fibrin sealant patch	Patch	125351	2010-04-05	⤷ Start Trial	⤷ Start Trial
Ethicon, Inc.	EVARREST	fibrin sealant patch	Patch	125392	2012-12-05	⤷ Start Trial	⤷ Start Trial
Instituto Grifols, S.a.	VISTASEAL	fibrin sealant (human)	Frozen	125640	2017-11-01	⤷ Start Trial	⤷ Start Trial
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Patent Expiration

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