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Last Updated: April 25, 2024

Patent: 7,863,430

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Summary for Patent: 7,863,430

Title:	Construct capable of release in closed circular form from a larger nucleotide sequence permitting site specific expression and/or developmentally regulated expression of selected genetic sequences
Abstract:	The present invention relates generally to constructs and in particular genetic constructs comprising polynucleotide sequences capable of release in covalently closed, circular form from a larger nucleotide sequence such as a genome of a eukaryotic cell. Preferably, once released, a polynucleotide sequence is reconstituted in a form which permits expression of the polynucleotide sequence. In one embodiment, the reconstituted polynucleotide sequence comprises a coding sequence with all or part of an extraneous nucleotide such as an intronic sequence or other splice signal inserted therein. Expression and in particular transcription of the coding sequence involves splicing out the extraneous sequence. The release and circularization is generally in response to a stimulus such as a protein-mediated stimulus. More particularly, the protein is a viral or prokaryotic or eukaryotic derived protein or developmentally and/or tissue specific regulated protein.
Inventor(s):	Dale; James Langham (Anstead, AU), Dugdale; Benjamin (Milton, AU), Hafner; Greg John (Carina, AU), Hermann; Scott Richard (Strathpine, AU), Becker; Douglas Kenneth (Alderley, AU), Harding; Robert Maxwell (Highgate Hill, AU), Chowpongpang; Srimek (Samut Sakhon, TH)
Assignee:	Queensland University of Technology (Brisbane, Queensland, AU)
Application Number:	10/168,653
Patent Claims:	see list of patent claims

Details for Patent 7,863,430

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986	⤷ Try a Trial	2020-03-28
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132		⤷ Try a Trial	2020-03-28
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132		⤷ Try a Trial	2020-03-28
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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