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Last Updated: August 3, 2020

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Patent: 5,811,633

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Summary for Patent: 5,811,633
Title: Transgenic mouse expressing APP.sub.770
Abstract:The construction of transgenic mouse models for testing potential treatments for Alzheimer\'s disease are described. The models are characterized by a greater similarity to the conditions existing in naturally occurring Alzheimer\'s disease, based on expression of all three forms of the .beta.-amyloid precursor protein (APP), APP.sub.695, APP.sub.751, and APP.sub.770), as well as various point mutations based on naturally occurring mutations, such as the London and Indiana familial Alzheimer\'s disease (FAD) mutations at amino acid 717, and predicted mutations in the APP gene. The APP gene constructs are prepared using the naturally occurring promoter, as well as inducible promoters such as the mouse metallothionine promoter, which can be regulated by addition of heavy metals such as zinc to the mouse\'s water or diet, and promoters such as the rat neuron specific enolase promoter, human .beta. actin gene promoter, human platelet derived growth factor B (PDGF-B) chain gene promoter, rat sodium channel gene promoter, mouse myelin basic protein gene promoter, human copper-zinc superoxide dismutase gene promoter, and mammalian POU-domain regulatory gene promoter. The constructs are introduced into mouse embryos using standard techniques such as microinjection. Mouse cells can be isolated from the transgenic mice or prepared using the same constructs with standard techniques such as lipofection or electroporation. The transgenic mice, or mouse cells, are used to screen for compounds altering the pathological course of Alzheimer\'s Disease as measured by their effect on the amount and histopathology of APP and .beta.-amyloid peptide in the mice, as well as by behavioral alterations.
Inventor(s): Wadsworth; Samuel (Shrewsbury, MA), Snyder; Benjamin (Worcester, MA), Wei; Cha-Mer (Framingham, MA), Leibowitz; Paul J. (Brookline, MA)
Application Number:08/482,027
Patent Claims:see list of patent claims

Details for Patent 5,811,633

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial 2015-09-22 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial 2015-09-22 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial 2015-09-22 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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