Last Updated: May 10, 2026

Patent: 5,691,169

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Summary for Patent: 5,691,169

Title:	Process for preparing a desired protein
Abstract:	A desired protein having the formula: A-B-C-P wherein a) A is Lys or Arg, and B and C are arbitrary amino acids, or b) A is an arbitrary amino acid different from Pro, Lys and Arg, and B and/or C is Pro, is produced from a biosynthetically formed amino acid extended protein having the formula: X-A-B-C-P wherein A, B, C and P are as defined above, and X is an amino acid sequence with an even number of amino acids, of which the first one, seen from the N-terminal end, is different from Lys and Arg, all other uneven amino acids are different from Pro, Lys and Arg, and all even amino acids are different from Pro, by reaction with the enzyme dipeptidyl aminopeptidase (DAP I). The desired protein is obtained in a pure state. Thus, e.g. hGH without content of Met-hGH may be produced by the process.
Inventor(s):	Henrik Dalb.o slashed.ge, John Pedersen, Thorkild Christensen, J.o slashed.rli Winnie Ringsted, Torben Ehlern Jessen
Assignee:	Novo Nordisk Health Care AG
Application Number:	US08/402,455
Patent Claims:	see list of patent claims

Details for Patent 5,691,169

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Novo Nordisk Inc.	NORDITROPIN	somatropin	Injection	021148	June 20, 2000	5,691,169	2015-03-10
Novo Nordisk Inc.	NORDITROPIN	somatropin	Injection	021148	October 01, 2004	5,691,169	2015-03-10
Novo Nordisk Inc.	NORDITROPIN	somatropin	Injection	021148	March 10, 2009	5,691,169	2015-03-10
Novo Nordisk Inc.	NORDITROPIN	somatropin	Injection	021148	March 01, 2010	5,691,169	2015-03-10
Novo Nordisk Inc.	NORDITROPIN	somatropin	Injection	021148	January 23, 2015	5,691,169	2015-03-10
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 5,691,169

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	8604609	⤷ Start Trial
World Intellectual Property Organization (WIPO)	8402351	⤷ Start Trial
United States of America	5679552	⤷ Start Trial
United States of America	5635604	⤷ Start Trial
United States of America	5633352	⤷ Start Trial
United States of America	5618697	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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