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Last Updated: September 27, 2021

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Patent: 10,544,125

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Summary for Patent: 10,544,125
Title:Process for preparing an anti-cancer agent, 1-((4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)meth- yl)cyclopropanamine, its crystalline form and its salts
Abstract: The present invention relates a new process to synthesize 1-((4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)meth- yl)cyclopropanamine (AL3818). A stable crystalline form of Al3818 has been prepared. Salts and their crystalline forms of AL3818 have been also prepared. Anti-cancer and optometric activities of AL3818 and its salts have been further tested. New process has been outlined in Scheme I. ##STR00001##
Inventor(s): Chen; Guoqing Paul (Westlake, CA), Yan; Changren (Camarillo, CA)
Assignee: Advenchen Pharmaceuticals, LLC (Moorpark, CA)
Application Number:16/125,401
Patent Claims:see list of patent claims

Details for Patent 10,544,125

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Bristol Myers Squibb YERVOY ipilimumab INJECTABLE; INJECTION 125377 001 2011-03-25 ⤷  Try it Free Advenchen Pharmaceuticals, LLC (Moorpark, CA) 2035-05-04 RX Orphan search
Merck Sharp Dohme KEYTRUDA pembrolizumab SOLUTION;INTRAVENOUS 125514 001 2014-09-04 ⤷  Try it Free Advenchen Pharmaceuticals, LLC (Moorpark, CA) 2035-05-04 RX Orphan search
Amgen Inc IMLYGIC talimogene laherparepvec INJECTION, SUSPENSION 125518 1 2015-11-02 ⤷  Try it Free Advenchen Pharmaceuticals, LLC (Moorpark, CA) 2035-05-04 search
Bristol Myers Squibb OPDIVO nivolumab INJECTABLE;INJECTION 125527 001 2015-03-04 ⤷  Try it Free Advenchen Pharmaceuticals, LLC (Moorpark, CA) 2035-05-04 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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