Last Updated: October 2, 2026

Patent: RE43691

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Summary for Patent: RE43691

Title:	C1 inhibitor with short half-life transient treatment
Abstract:	The present invention relates to the use of a C1 inhibitor (C1INH) with shorter half-life than plasma-derived C1INH for the preparation of a medicament for the transient treatment of an individual. It relates to both therapeutic and prophylactic treatment. The method of the invention allows for the administration of C1INH at certain therapeutic levels for a concise pre-determined time span. Pharmaceutical compositions based on C1INH with shorter half-lives may be used both in situations where transient treatment is merely and advantage. The advantage of the use according to the invention is that an individual is not exposed to C1INH for longer than required, since the levels of the C1INH more rapidly subsides after administration has stopped. In contrast, levels of plasma-derived C1INH would remain elevated for a prolonged period of time.
Inventor(s):	Johannes Henricus Nuijens
Assignee:	Pharming Intellectual Property BV
Application Number:	US13/157,176
Patent Claims:	see list of patent claims

Details for Patent RE43691

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Pharming Americas Bv	RUCONEST	c1 esterase inhibitor (recombinant)	For Injection	125495	16-Jul-14	⤷ Start Trial	2024-05-14
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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