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Last Updated: October 29, 2020

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Patent: 9,896,509

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Summary for Patent: 9,896,509
Title:Use of antagonists of the interaction between HIV GP120 and .alpha.4.beta.7 integrin
Abstract: Methods are provided for the treatment of a HIV infection. The methods can include administering to a subject with an HIV infection a therapeutically effective amount of an agent that interferes with the interaction of gp120 and .alpha.4 integrin, such as a .alpha.4.beta.1 or .alpha.4.beta.7 integrin antagonist, thereby treating the HIV infection. In several examples, the .alpha.4 integrin antagonist is a monoclonal antibody that specifically binds to a .alpha.4, .beta.1 or .beta.7 integrin subunit or a cyclic hexapeptide with the amino acid sequence of CWLDVC. Methods are also provided to reduce HIV replication or infection. The methods include contacting a cell with an effective amount of an agent that interferes with the interaction of gp120 and .alpha.4 integrin, such as a .alpha.4.beta.1 or .alpha.4.beta.7 integrin antagonist. Moreover, methods are provided for determining if an agent is useful to treat HIV.
Inventor(s): Arthos; James (Bethesda, MD), Goode; Diana (Bellingham, MA), Cicala; Claudia (Bethesda, MD), Fauci; Anthony S. (Bethesda, MD)
Assignee: The United States of America, as Represented by the Secretary, Department of Health and Human Services (Washington, DC)
Application Number:15/227,879
Patent Claims:see list of patent claims

Details for Patent 9,896,509

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Biogen Idec TYSABRI natalizumab VIAL; SINGLE-USE 125104 001 2004-11-23   Start Trial The United States of America, as Represented by the Secretary, Department of Health and Human Services (Washington, DC) 2026-12-07 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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