Patent: 9,745,334
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Summary for Patent: 9,745,334
| Title: | Cytotoxic-drug delivering molecules targeting HIV (CDM-Hs), cytotoxic activity against the human immunodeficiency virus and methods of use |
| Abstract: | The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as CDM-Hs, function through orthogonal pathways, by inhibiting the gp120-CD4 interaction, and by introducing cytotoxic moieties to gp120-expressing cells, thereby causing cell death and preventing cell infection and spread of HIV. It is shown that CDM-Hs bind to gp120 and gp-120 expressing cells competitively with CD4, and these compounds cause cell death of HIV-infected cells, thereby decreasing viral infectivity. Compounds and methods are described herein. |
| Inventor(s): | Spiegel; David (New Haven, CT), Parker; Christopher (Medina, OH) |
| Assignee: | YALE UNIVERSITY (New Haven, CT) |
| Application Number: | 14/396,956 |
| Patent Claims: | see list of patent claims |
Details for Patent 9,745,334
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
|---|---|---|---|---|---|---|---|
| Eli Lilly And Company | HUMATROPE | somatropin | For Injection | 019640 | 06/23/1987 | ⤷ Try a Trial | 2032-04-26 |
| Eli Lilly And Company | HUMATROPE | somatropin | For Injection | 019640 | 10/16/1986 | ⤷ Try a Trial | 2032-04-26 |
| Eli Lilly And Company | HUMATROPE | somatropin | For Injection | 019640 | 02/04/1999 | ⤷ Try a Trial | 2032-04-26 |
| Emd Serono, Inc. | SAIZEN | somatropin | For Injection | 019764 | 10/08/1996 | ⤷ Try a Trial | 2032-04-26 |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
