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Last Updated: November 29, 2021

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Patent: 9,683,985

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Summary for Patent: 9,683,985
Title:Methods for assessing and identifying or evolving conditionally active therapeutic proteins
Abstract: Methods for evolving or selecting or producing therapeutic proteins that exhibit reduced adverse side-effects and the resulting proteins are provided. For example, provided herein is an in vitro assay to identify conditionally active therapeutic proteins that exhibit better activity within one in vivo environment compared to another in vivo environment. The methods include the steps of a) testing the activity of a protein under conditions in which normal or increased activity is desired; b) testing the activity of the protein under conditions in which reduced activity compared to normal is desired; and c) comparing the activity in a) with b) and selecting/identifying a protein that has greater activity in a) compared to b). The selected/identified protein is a conditionally active protein.
Inventor(s): Kodandapani; Lalitha (San Diego, CA), Bookbinder; Louis H. (San Diego, CA), Frost; Gregory I. (Del Mar, CA), Sheridan; Philip Lee (San Diego, CA), Shepard; Harold Michael (San Diego, CA), Wei; Ge (San Diego, CA), Huang; Lei (San Diego, CA)
Assignee: Halozyme, Inc. (San Diego, CA)
Application Number:13/200,666
Patent Claims:see list of patent claims

Details for Patent 9,683,985

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. RITUXAN rituximab Injection 103705 1997-11-26 ⤷  Try it Free 2030-09-08
Idec Pharmaceuticals Corp. RITUXAN rituximab Injection 103737 2002-02-19 ⤷  Try it Free 2030-09-08
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 1998-09-25 ⤷  Try it Free 2030-09-08
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 2017-02-10 ⤷  Try it Free 2030-09-08
Genzyme Corporation CAMPATH alemtuzumab Injection 103948 2001-05-07 ⤷  Try it Free 2030-09-08
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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