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Last Updated: May 7, 2024

Patent: 9,644,008

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Summary for Patent: 9,644,008

Title:	Deglycosylated hemagglutinin and manufacture thereof
Abstract:	The invention provides a deglycosylated hemagglutinin, wherein the glycosylation site(s) on the stem region is removed. The deglycosylated hemagglutinin may induce neutralizing antibody against influenza virus, and cross-reactive protection against different virus. The invention also provides a method for manufacturing deglycosylated hemagglutinin, comprising aligning two or more hemagglutinin stem sequences of influenza virus, identifying the high conserved N-glycosylation site, and removing the high conserved N-glycosylation site. Thus, the N-glycosylation site cannot be glycosylated.
Inventor(s):	Wu; Suh-Chin (Hsinchu, TW), Liu; Wen-Chun (Hsinchu, TW), Huang; Yun-Ju (Hsinchu, TW)
Assignee:	National Tsing Hua University (Hsinchu, TW)
Application Number:	14/201,276
Patent Claims:	see list of patent claims

Details for Patent 9,644,008

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Seqirus Vaccines Limited	FLUVIRIN	influenza virus vaccine	Injection	103837	11/03/1998	⤷ Try a Trial	2033-12-27
Sanofi Pasteur Inc.	FLUZONE, FLUZONE HD QUADRIVALENT, FLUZONE HIGH DOSE, FLUZONE INTRADERMAL, FLUZONE QUADRIVALENT	influenza virus vaccine	Injection	103914	12/09/1999	⤷ Try a Trial	2033-12-27
Sanofi Pasteur Inc.	FLUZONE, FLUZONE HD QUADRIVALENT, FLUZONE HIGH DOSE, FLUZONE INTRADERMAL, FLUZONE QUADRIVALENT	influenza virus vaccine	Injection	103914	12/23/1909	⤷ Try a Trial	2033-12-27
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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