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Last Updated: January 26, 2020

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Patent: 9,616,114

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Summary for Patent: 9,616,114
Title:Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
Abstract: Bacterial strains are provided having at least one of a reduced size, a sialic acid coat, inducibly altered surface antigens, and expression of PD-L1 or CTLA-4 agonists and/or tryptophanase. The bacteria may have improved serum half-life, increased penetration into tumors, increased tumor targeting and increased antitumor activity. The bacteria are useful for delivery of therapeutic agents that treat of neoplastic diseases including solid tumors and lymphomas.
Inventor(s): Bermudes; David Gordon (Woodland Hills, CA)
Application Number:14/858,810
Patent Claims:see list of patent claims

Details for Patent 9,616,114

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial 2034-09-18 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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