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Generated: September 19, 2017

Patent: ► Subscribe

Summary for Patent: ► Subscribe

Title:Stable heterodimeric antibody design with mutations in the Fc domain
Abstract: The provided scaffolds have heavy chains that are asymmetric in the various domains (e.g. CH2 and CH3) to accomplish selectivity between the various Fc receptors involved in modulating effector function, beyond those achievable with a natural homodimeric (symmetric) Fc molecule, and increased stability and purity of the resulting variant Fc heterodimers. These novel molecules comprise complexes of heterogeneous components designed to alter the natural way antibodies behave and that find use in therapeutics.
Inventor(s): Spreter Von Kreudenstein; Thomas (Vancouver, CA), Dixit; Surjit Bhimarao (Richmond, CA), Escobar-Cabrera; Eric (Burnaby, CA), Lario; Paula Irene (Vancouver, CA), Poon; David Kai Yuen (Richmond, CA)
Assignee: Zymeworks Inc. (Vancouver, CA)
Application Number:13/668,098
Patent Claim Types:
see list of patent claims
Compound; Composition;

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Inventors Patent Expiration Status Orphan Source
Genentech
RITUXAN
rituximab
VIAL1037050011997-11-26► Subscribe Zymeworks Inc. (Vancouver, CA) Spreter Von Kreudenstein; Thomas (Vancouver, CA), Dixit; Surjit Bhimarao (Richmond, CA), Escobar-Cabrera; Eric (Burnaby, CA), Lario; Paula Irene (Vancouver, CA), Poon; David Kai Yuen (Richmond, CA) ► SubscribeRXsearch
Novartis
SIMULECT
basiliximab
VIAL; SINGLE-USE1037640011998-05-12► Subscribe Zymeworks Inc. (Vancouver, CA) Spreter Von Kreudenstein; Thomas (Vancouver, CA), Dixit; Surjit Bhimarao (Richmond, CA), Escobar-Cabrera; Eric (Burnaby, CA), Lario; Paula Irene (Vancouver, CA), Poon; David Kai Yuen (Richmond, CA) ► SubscribeRXsearch
Novartis
SIMULECT
basiliximab
VIAL; SINGLE-USE1037640021998-05-12► Subscribe Zymeworks Inc. (Vancouver, CA) Spreter Von Kreudenstein; Thomas (Vancouver, CA), Dixit; Surjit Bhimarao (Richmond, CA), Escobar-Cabrera; Eric (Burnaby, CA), Lario; Paula Irene (Vancouver, CA), Poon; David Kai Yuen (Richmond, CA) ► SubscribeRXsearch
Medimmune
SYNAGIS
palivizumab
VIAL1037700011998-06-19► Subscribe Zymeworks Inc. (Vancouver, CA) Spreter Von Kreudenstein; Thomas (Vancouver, CA), Dixit; Surjit Bhimarao (Richmond, CA), Escobar-Cabrera; Eric (Burnaby, CA), Lario; Paula Irene (Vancouver, CA), Poon; David Kai Yuen (Richmond, CA) ► SubscribeRXsearch
Medimmune
SYNAGIS
palivizumab
VIAL1037700021998-06-19► Subscribe Zymeworks Inc. (Vancouver, CA) Spreter Von Kreudenstein; Thomas (Vancouver, CA), Dixit; Surjit Bhimarao (Richmond, CA), Escobar-Cabrera; Eric (Burnaby, CA), Lario; Paula Irene (Vancouver, CA), Poon; David Kai Yuen (Richmond, CA) ► SubscribeRXsearch
Centocor Inc
REMICADE
infliximab
VIAL1037720011998-08-24► Subscribe Zymeworks Inc. (Vancouver, CA) Spreter Von Kreudenstein; Thomas (Vancouver, CA), Dixit; Surjit Bhimarao (Richmond, CA), Escobar-Cabrera; Eric (Burnaby, CA), Lario; Paula Irene (Vancouver, CA), Poon; David Kai Yuen (Richmond, CA) ► SubscribeRXOrphansearch
Genentech
HERCEPTIN
trastuzumab
VIAL; INTRAVENOUS1037920011998-09-25► Subscribe Zymeworks Inc. (Vancouver, CA) Spreter Von Kreudenstein; Thomas (Vancouver, CA), Dixit; Surjit Bhimarao (Richmond, CA), Escobar-Cabrera; Eric (Burnaby, CA), Lario; Paula Irene (Vancouver, CA), Poon; David Kai Yuen (Richmond, CA) ► SubscribeRXOrphansearch
Genzyme
CAMPATH
alemtuzumab
VIAL; INTRAVENOUS1039480012001-05-07► Subscribe Zymeworks Inc. (Vancouver, CA) Spreter Von Kreudenstein; Thomas (Vancouver, CA), Dixit; Surjit Bhimarao (Richmond, CA), Escobar-Cabrera; Eric (Burnaby, CA), Lario; Paula Irene (Vancouver, CA), Poon; David Kai Yuen (Richmond, CA) ► SubscribeRXOrphansearch
Genzyme
CAMPATH
alemtuzumab
VIAL; INTRAVENOUS1039480022001-05-07► Subscribe Zymeworks Inc. (Vancouver, CA) Spreter Von Kreudenstein; Thomas (Vancouver, CA), Dixit; Surjit Bhimarao (Richmond, CA), Escobar-Cabrera; Eric (Burnaby, CA), Lario; Paula Irene (Vancouver, CA), Poon; David Kai Yuen (Richmond, CA) ► SubscribeRXOrphansearch
Genzyme
LEMTRADA
alemtuzumab
INJECTABLE;INJECTION1039480032001-05-07► Subscribe Zymeworks Inc. (Vancouver, CA) Spreter Von Kreudenstein; Thomas (Vancouver, CA), Dixit; Surjit Bhimarao (Richmond, CA), Escobar-Cabrera; Eric (Burnaby, CA), Lario; Paula Irene (Vancouver, CA), Poon; David Kai Yuen (Richmond, CA) ► SubscribeRXOrphansearch
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International Patent Family for Patent: ► Subscribe

Country Document Number Publication Date
Australia2012332021Jun 19, 2014
Australia2013258844Dec 04, 2014
Australia2013289881Feb 26, 2015
Australia2013289883Feb 19, 2015
Australia2013337578May 21, 2015
Australia2014287011Feb 25, 2016
Australia2014287011Mar 10, 2016
Australia2015206407Aug 18, 2016
Brazil112014010580May 02, 2017
Canada2854233May 10, 2013
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Serving 500+ biopharmaceutical companies globally:

Covington
Chubb
Daiichi Sankyo
Deloitte
Baxter
Cerilliant
Express Scripts
Accenture
Merck
US Army

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