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Last Updated: August 10, 2020

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Patent: 9,562,038

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Summary for Patent: 9,562,038
Title:Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the human immunodeficiency virus
Abstract: The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as ARM-HI\'s, function through orthogonal pathways, by inhibiting the gp120-CD4 interaction, and by recruiting anti-DNP antibodies to gp120-expressing cells, thereby preventing cell infection and spread of HIV. It has been shown that ARM-HI\'s bind to gp120 and gp-120 expressing cells competitively with CD4, thereby decreasing viral infectivity as shown by an MT-2 cell assay, the binding leading to formation of a ternary complex by recruiting anti-DNP antibodies to bind thereto, the antibodies present in the ternary complex promoting the complement-dependent destruction of the gp120-expressing cells. Compounds and methods are described herein.
Inventor(s): Spiegel; David (New Haven, CT), Parker; Christopher (Medina, OH)
Assignee: YALE UNIVERSITY (New Haven, CT)
Application Number:13/988,251
Patent Claims:see list of patent claims

Details for Patent 9,562,038

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Octapharma Usa Inc OCTAGAM IMMUNE GLOBULIN (HUMAN) immune globulin SOLUTION 125062 1 2004-05-21   Start Trial YALE UNIVERSITY (New Haven, CT) 2030-11-18 search
Chiron PROLEUKIN aldesleukin VIAL 103293 001 1992-05-05   Start Trial YALE UNIVERSITY (New Haven, CT) 2030-11-18 RX search
Amgen EPOGEN/PROCRIT epoetin alfa VIAL; SINGLE-USE 103234 007 1989-06-01   Start Trial YALE UNIVERSITY (New Haven, CT) 2030-11-18 RX search
Amgen EPOGEN/PROCRIT epoetin alfa VIAL; SINGLE-USE 103234 006 1989-06-01   Start Trial YALE UNIVERSITY (New Haven, CT) 2030-11-18 RX search
Amgen EPOGEN/PROCRIT epoetin alfa VIAL; SINGLE-USE 103234 005 1989-06-01   Start Trial YALE UNIVERSITY (New Haven, CT) 2030-11-18 RX search
Amgen EPOGEN/PROCRIT epoetin alfa VIAL; SINGLE-USE 103234 004 1989-06-01   Start Trial YALE UNIVERSITY (New Haven, CT) 2030-11-18 RX search
Amgen EPOGEN/PROCRIT epoetin alfa VIAL; MULTIDOSE 103234 003 1989-06-01   Start Trial YALE UNIVERSITY (New Haven, CT) 2030-11-18 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

International Patent Family for US Patent 9,562,038

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