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Last Updated: December 7, 2021

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Patent: 9,562,038

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Summary for Patent: 9,562,038
Title:Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the human immunodeficiency virus
Abstract: The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as ARM-HI\'s, function through orthogonal pathways, by inhibiting the gp120-CD4 interaction, and by recruiting anti-DNP antibodies to gp120-expressing cells, thereby preventing cell infection and spread of HIV. It has been shown that ARM-HI\'s bind to gp120 and gp-120 expressing cells competitively with CD4, thereby decreasing viral infectivity as shown by an MT-2 cell assay, the binding leading to formation of a ternary complex by recruiting anti-DNP antibodies to bind thereto, the antibodies present in the ternary complex promoting the complement-dependent destruction of the gp120-expressing cells. Compounds and methods are described herein.
Inventor(s): Spiegel; David (New Haven, CT), Parker; Christopher (Medina, OH)
Assignee: YALE UNIVERSITY (New Haven, CT)
Application Number:13/988,251
Patent Claims:see list of patent claims

Details for Patent 9,562,038

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Eli Lilly And Company HUMATROPE somatropin For Injection 019640 1987-06-23 ⤷  Try it Free 2030-11-18
Eli Lilly And Company HUMATROPE somatropin For Injection 019640 1986-10-16 ⤷  Try it Free 2030-11-18
Eli Lilly And Company HUMATROPE somatropin For Injection 019640 1999-02-04 ⤷  Try it Free 2030-11-18
Emd Serono, Inc. SAIZEN somatropin For Injection 019764 1996-10-08 ⤷  Try it Free 2030-11-18
Emd Serono, Inc. SAIZEN somatropin For Injection 019764 2000-08-29 ⤷  Try it Free 2030-11-18
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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