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Generated: September 19, 2017

Patent: ► Subscribe

Summary for Patent: ► Subscribe

Title:TLR-agonist-conjugated antibody recruiting molecules (TLR-ARMs)
Abstract: The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) and Toll-like receptor agonist (TLR) through a linker and a multifunctional connector group or molecule.
Inventor(s): Spiegel; David (New Haven, CT), Fitzgerald; Kelly (New Haven, CT)
Assignee: YALE UNIVERSITY (New Haven, CT)
Application Number:14/397,995
Patent Claim Types:
see list of patent claims
Compound; Composition; Dosage form; Use;

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Inventors Patent Expiration Status Orphan Source
Schering
INTRON A
interferon alfa-2b
VIAL1031320011986-06-04► Subscribe YALE UNIVERSITY (New Haven, CT) Spiegel; David (New Haven, CT), Fitzgerald; Kelly (New Haven, CT) ► SubscribeRXsearch
Schering
INTRON A
interferon alfa-2b
VIAL1031320021986-06-04► Subscribe YALE UNIVERSITY (New Haven, CT) Spiegel; David (New Haven, CT), Fitzgerald; Kelly (New Haven, CT) ► SubscribeRXsearch
Schering
INTRON A
interferon alfa-2b
VIAL1031320031986-06-04► Subscribe YALE UNIVERSITY (New Haven, CT) Spiegel; David (New Haven, CT), Fitzgerald; Kelly (New Haven, CT) ► SubscribeRXsearch
Chiron
PROLEUKIN
aldesleukin
VIAL1032930011992-05-05► Subscribe YALE UNIVERSITY (New Haven, CT) Spiegel; David (New Haven, CT), Fitzgerald; Kelly (New Haven, CT) ► SubscribeRXsearch
Berlex Labs
LEUKINE
sargramostim
VIAL1033620011991-03-05► Subscribe YALE UNIVERSITY (New Haven, CT) Spiegel; David (New Haven, CT), Fitzgerald; Kelly (New Haven, CT) ► SubscribeRXsearch
Berlex Labs
LEUKINE
sargramostim
VIAL1033620021991-03-05► Subscribe YALE UNIVERSITY (New Haven, CT) Spiegel; David (New Haven, CT), Fitzgerald; Kelly (New Haven, CT) ► SubscribeRXsearch
Sigma Tau
ONCASPAR
pegaspargase
VIAL1034110011994-02-01► Subscribe YALE UNIVERSITY (New Haven, CT) Spiegel; David (New Haven, CT), Fitzgerald; Kelly (New Haven, CT) ► SubscribeRXsearch
Genentech
RITUXAN
rituximab
VIAL1037050011997-11-26► Subscribe YALE UNIVERSITY (New Haven, CT) Spiegel; David (New Haven, CT), Fitzgerald; Kelly (New Haven, CT) ► SubscribeRXsearch
Genentech
HERCEPTIN
trastuzumab
VIAL; INTRAVENOUS1037920011998-09-25► Subscribe YALE UNIVERSITY (New Haven, CT) Spiegel; David (New Haven, CT), Fitzgerald; Kelly (New Haven, CT) ► SubscribeRXOrphansearch
Sanofi Synthelabo
ELITEK
rasburicase
VIAL; INTRAVENOUS1039460012002-07-12► Subscribe YALE UNIVERSITY (New Haven, CT) Spiegel; David (New Haven, CT), Fitzgerald; Kelly (New Haven, CT) ► SubscribeRXsearch
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Summary for Patent: ► Subscribe

PCT Information
PCT FiledMay 01, 2013PCT Application Number:PCT/US2013/039007
PCT Publication Date:November 07, 2013PCT Publication Number: WO2013/166110

International Patent Family for Patent: ► Subscribe

Country Document Number Publication Date
United States of America2015110742Apr 23, 2015
United States of America2017087148Mar 30, 2017
World Intellectual Property Organization (WIPO)2013166110Nov 07, 2013
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Serving 500+ biopharmaceutical companies globally:

Fish and Richardson
Julphar
Medtronic
Moodys
Colorcon
UBS
AstraZeneca
Baxter
Daiichi Sankyo
Argus Health

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