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Generated: July 21, 2019

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Patent: 9,527,857

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Summary for Patent: 9,527,857
Title:HSPC-sparing treatments for RB-positive abnormal cellular proliferation
Abstract: This invention is in the area of improved compounds for and methods of treating selected RB-positive cancers and other Rb-positive abnormal cellular proliferative disorders while minimizing the deleterious effects on healthy cells, for example healthy Hematopoietic Stem Cells and Progenitor Cells (HSPCs), associated with current treatment modalities. In one aspect, improved treatment of select RB-positive cancers is disclosed using specific compounds disclosed herein. In certain embodiments, the compounds described herein act as highly selective and, in certain embodiments, short, transiently-acting cyclin-dependent kinase 4/6 (CDK 4/6) inhibitors when administered to subjects.
Inventor(s): Strum; Jay Copeland (Hillsborough, NC), Bisi; John Emerson (Apex, NC), Roberts; Patrick Joseph (Durham, NC), Tavares; Francis Xavier (Durham, NC)
Assignee: GI Therapeutics, Inc. (Research Triangle Park, NC)
Application Number:14/214,048
Patent Claims:see list of patent claims

Details for Patent 9,527,857

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Genentech KADCYLA ado-trastuzumab emtansine VIAL; SINGLE-USE 125427 002 2013-02-22 ➤ Sign Up GI Therapeutics, Inc. (Research Triangle Park, NC) ➤ Sign Up RX search
Genentech KADCYLA ado-trastuzumab emtansine VIAL; SINGLE-USE 125427 001 2013-02-22 ➤ Sign Up GI Therapeutics, Inc. (Research Triangle Park, NC) ➤ Sign Up RX search
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25 ➤ Sign Up GI Therapeutics, Inc. (Research Triangle Park, NC) ➤ Sign Up RX Orphan search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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International Patent Family for US Patent 9,527,857

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Serving hundreds of leading biopharmaceutical companies globally:

Fish and Richardson
Merck
Argus Health
US Army
Accenture
Chubb

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