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Serving 500+ biopharmaceutical companies globally:

AstraZeneca
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Covington
Mallinckrodt
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Generated: September 19, 2017

Patent: ► Subscribe

Summary for Patent: ► Subscribe

Title:Cytotoxic and anti-mitotic compounds, and methods of using the same
Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. The compounds have the following structure (I): ##STR00001## including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having structure (I).
Inventor(s): Winters; Geoffrey C. (Vancouver, CA), Mandel; Alexander L. (Vancouver, CA), Hedberg; Bradley J. (Vancouver, CA), Babcook; John (Vancouver, CA), Rich; James R. (Vancouver, CA), Hsieh; Tom Han Hsiao (Vancouver, CA), Bourque; Elyse Marie Josee (Blaine, WA)
Assignee: ZYMEWORKS INC. (Vancouver, BC, unknown)
Application Number:14/213,504
Patent Claim Types:
see list of patent claims
Compound; Use; Composition;

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Inventors Patent Expiration Status Orphan Source
Genentech
HERCEPTIN
trastuzumab
VIAL; INTRAVENOUS1037920011998-09-25► Subscribe ZYMEWORKS INC. (Vancouver, BC, unknown) Winters; Geoffrey C. (Vancouver, CA), Mandel; Alexander L. (Vancouver, CA), Hedberg; Bradley J. (Vancouver, CA), Babcook; John (Vancouver, CA), Rich; James R. (Vancouver, CA), Hsieh; Tom Han Hsiao (Vancouver, CA), Bourque; Elyse Marie Josee (Blaine, WA) ► SubscribeRXOrphansearch
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International Patent Family for Patent: ► Subscribe

Country Document Number Publication Date
Australia2014228489Sep 24, 2015
Canada2906784Sep 18, 2014
China105358174Feb 24, 2016
Eurasian Patent Organization201591632Apr 29, 2016
European Patent Office2968440Aug 17, 2016
European Patent Office2968440Jan 20, 2016
Hong Kong1220140Apr 28, 2017
Hong Kong1220626May 12, 2017
Japan2016516063Jun 02, 2016
South Korea20160009019Jan 25, 2016
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Serving 500+ biopharmaceutical companies globally:

Medtronic
Fish and Richardson
Harvard Business School
McKesson
Cerilliant
Boehringer Ingelheim
Moodys
Daiichi Sankyo
Fuji
Dow

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