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Last Updated: November 27, 2021

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Patent: 9,434,786

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Summary for Patent: 9,434,786
Title:Chemoenzymatic glycoengineering of antibodies and Fc fragments thereof
Abstract: The present invention provides for recombinant Endo-S mutants that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sialylated oxazoline or synthetic oligosaccharide oxazoline is added to a core fucosylated or nonfucosylated GlcNAc-protein acceptor. Such recombinant Endo-S mutants are useful for efficient glycosylation remodeling of IgG1-Fc domain to provide different antibody glycoforms carrying structurally well-defined Fc N-glycans.
Inventor(s): Wang; Lai-Xi (Ellicott City, MD), Huang; Wei (Shanghai, CN)
Assignee: UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, MD)
Application Number:14/376,248
Patent Claims:see list of patent claims

Details for Patent 9,434,786

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Centocor Ortho Biotech Products, L.p. ORTHOCLONE OKT3 muromanab-cd3 Injection 103463 1992-09-14 ⤷  Try it Free 2032-02-10
Janssen Biotech, Inc. REOPRO abciximab Injection 103575 1994-12-22 ⤷  Try it Free 2032-02-10
Genentech, Inc. RITUXAN rituximab Injection 103705 1997-11-26 ⤷  Try it Free 2032-02-10
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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