Last Updated: November 8, 2026

Patent: 8,545,831

Summary for Patent: 8,545,831

Title:	Compositions and methods for treating a damaged cardiovascular element
Abstract:	In the present invention, the applicants describe methods and compositions of treating damaged cardiovascular elements and cardiovascular conditions including hypotension, atherosclerotic lesions, vulnerable plaque, and acute myocardial infarct. The applicants demonstrate the ability of a biomembrane sealing agent to accumulate on the walls of damaged blood vessels and help improving mean arterial pressure following tissue injury. The applicants describe the use of formulations comprising at least one biomembrane sealing agent and one bioactive agent for prophylactic treatment such as they could be administered concurrently to an invasive therapeutic intervention or after the insult (i.e. post-injury or post-surgery). Alternatively, these methods and compositions could be used to reduce the severity of cardiovascular diseases after onset.
Inventor(s):	Josee Roy, Hezi-Yamit Ayala, Carol Sullivan, Mingfei Chen
Assignee:	Warsaw Orthopedic Inc
Application Number:	US11/443,594
Patent Claims:	see list of patent claims

Details for Patent 8,545,831

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Glaxosmithkline Llc	TANZEUM	albiglutide	For Injection	125431	April 15, 2014	⤷ Start Trial	2026-05-31
Biogen Inc.	ZINBRYTA	daclizumab	Injection	761029	May 27, 2016	⤷ Start Trial	2026-05-31
Biogen Inc.	ZINBRYTA	daclizumab	Injection	761029	May 26, 2017	⤷ Start Trial	2026-05-31
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 8,545,831

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Country	Patent Number	Estimated Expiration
Australia	2006252616	⤷ Start Trial
Canada	2609196	⤷ Start Trial
European Patent Office	1890712	⤷ Start Trial
Japan	2008542381	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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