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Last Updated: April 26, 2024

Patent: 8,455,439

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Summary for Patent: 8,455,439

Title:	Antidotes for factor Xa inhibitors and methods of using the same in combination with blood coagulating agents
Abstract:	The present invention relates to antidotes of anticoagulants targeting factor Xa which antidotes are used in combination with blood coagulating agents or other heparin antidotes to prevent or reduce bleeding in a subject. The antidotes described herein have reduced or no intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is or will be undergoing anticoagulant therapy with a factor Xa inhibitor.
Inventor(s):	Lu; Genmin (Burlingame, CA), Sinha; Uma (San Francisco, CA)
Assignee:	Portola Pharmaceuticals, Inc. (South San Francisco, CA)
Application Number:	12/616,735
Patent Claims:	see list of patent claims

Details for Patent 8,455,439

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Bayer Healthcare Pharmaceuticals Inc.	TRASYLOL	aprotinin	Injection	020304	12/29/1993	⤷ Try a Trial	2028-11-14
Baxalta Us Inc.	AUTOPLEX, FEIBA NF, FEIBA VH	anti-inhibitor coagulant complex	For Injection	101447	12/21/1979	⤷ Try a Trial	2028-11-14
Baxalta Us Inc.	AUTOPLEX, FEIBA NF, FEIBA VH	anti-inhibitor coagulant complex	For Injection	101447	07/31/2000	⤷ Try a Trial	2028-11-14
Baxalta Us Inc.	AUTOPLEX, FEIBA NF, FEIBA VH	anti-inhibitor coagulant complex	For Injection	101447	08/11/2005	⤷ Try a Trial	2028-11-14
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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