Last Updated: June 28, 2026

Patent: 8,288,127

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Summary for Patent: 8,288,127

Title:	Protein expression systems
Abstract:	The present invention provides an improved expression system for the production of recombinant polypeptides utilizing auxotrophic selectable markers. In addition, the present invention provides improved recombinant protein production in host cells through the improved regulation of expression.
Inventor(s):	Schneider Jane C., Chew Lawrence C., Badgley Anne Kathryn, Ramseier Thomas Martin
Assignee:	Pfenex, Inc
Application Number:	US12512930
Patent Claims:	see list of patent claims

Details for Patent 8,288,127

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Jazz Pharmaceuticals Ireland Limited	RYLAZE	asparaginase erwinia chrysanthemi (recombinant)-rywn	Injection	761179	June 30, 2021	⤷ Start Trial	2029-07-30
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 8,288,127

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Country	Patent Number	Estimated Expiration
Australia	2004293810	⤷ Start Trial
Brazil	PI0416744	⤷ Start Trial
Canada	2545610	⤷ Start Trial
China	1906294	⤷ Start Trial
European Patent Office	1692282	⤷ Start Trial
Japan	2007511238	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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