Patent: 8,129,145
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Summary for Patent: 8,129,145
Title: | Production of glycoproteins |
Abstract: | An improved system for large scale production of glycoproteins in cell culture is provided. In accordance with the present invention, cells expressing a glycoprotein are grown in media that contain manganese at a concentration of between approximately 10 and 600 nM. The use of such a system allows production of a glycoprotein with an increased glycosylation pattern and/or a glycosylation pattern that more accurately reflects the glycosylation pattern of the naturally occurring glycoprotein. A glycoprotein expressed in accordance with the present invention may be advantageously used in the preparation of pharmaceutical compositions. |
Inventor(s): | Lasko; Daniel R. (Medford, MA), Koza; Stephan M. (Newbury, MA) |
Assignee: | Wyeth LLC (Madison, NJ) |
Application Number: | 11/827,301 |
Patent Claims: | see list of patent claims |
Details for Patent 8,129,145
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Wyeth Pharmaceuticals Llc | BENEFIX, BENEFIX RTS | coagulation factor ix (recombinant) | For Injection | 103677 | 02/11/1997 | ⤷ Try a Trial | 2026-07-13 |
Wyeth Pharmaceuticals Llc | BENEFIX, BENEFIX RTS | coagulation factor ix (recombinant) | For Injection | 103677 | 03/21/2007 | ⤷ Try a Trial | 2026-07-13 |
Wyeth Pharmaceuticals Llc | BENEFIX, BENEFIX RTS | coagulation factor ix (recombinant) | For Injection | 103677 | 11/23/2011 | ⤷ Try a Trial | 2026-07-13 |
Medexus Pharma, Inc. | IXINITY | coagulation factor ix (recombinant) | For Injection | 125426 | 04/29/2015 | ⤷ Try a Trial | 2026-07-13 |
Medexus Pharma, Inc. | IXINITY | coagulation factor ix (recombinant) | For Injection | 125426 | 12/21/2015 | ⤷ Try a Trial | 2026-07-13 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |