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Last Updated: September 22, 2020

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Patent: 8,129,145

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Summary for Patent: 8,129,145
Title:Production of glycoproteins
Abstract: An improved system for large scale production of glycoproteins in cell culture is provided. In accordance with the present invention, cells expressing a glycoprotein are grown in media that contain manganese at a concentration of between approximately 10 and 600 nM. The use of such a system allows production of a glycoprotein with an increased glycosylation pattern and/or a glycosylation pattern that more accurately reflects the glycosylation pattern of the naturally occurring glycoprotein. A glycoprotein expressed in accordance with the present invention may be advantageously used in the preparation of pharmaceutical compositions.
Inventor(s): Lasko; Daniel R. (Medford, MA), Koza; Stephan M. (Newbury, MA)
Assignee: Wyeth LLC (Madison, NJ)
Application Number:11/827,301
Patent Claims:see list of patent claims

Details for Patent 8,129,145

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Wyeth Biopharma Division Of Wyeth Pharmaceuticals Llc BENEFIX coagulation factor ix (recombinant) KIT 103677 1 2012-02-01   Start Trial Wyeth LLC (Madison, NJ) 2026-07-13 search
Aptevo Biotherapeutics Llc IXINITY coagulation factor ix (recombinant) KIT 125426 1 2017-05-12   Start Trial Wyeth LLC (Madison, NJ) 2026-07-13 search
Baxalta Us Inc. RIXUBIS coagulation factor ix (recombinant) KIT 125446 1 2013-10-04   Start Trial Wyeth LLC (Madison, NJ) 2026-07-13 search
Csl Behring Lengnau Ag IDELVION coagulation factor ix recombinant human KIT 125582 1 2018-05-30   Start Trial Wyeth LLC (Madison, NJ) 2026-07-13 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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