Last Updated: September 24, 2026

Patent: 8,088,416

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Summary for Patent: 8,088,416

Title:	Process for obtaining high efficiency human albumin for use in detoxification therapy
Abstract:	A process for purifying and collecting albumin from plasma and plasma fractions involves diafiltration of an albumin-containing plasma fraction; stabilizing the resulting albumin fraction with sodium chloride and an amino acid in the absence of any added fatty acid; pasteurizing the stabilized albumin fraction; and diafiltering the pasteurized fraction to remove, along other things, stabilizers. In one embodiment, the amino acid stabilizing agent is acetyl tryptophan. The resulting albumin has at least about 80% albumin binding capacity relative to natural plasma albumin, and is storage stable for about 30 months at 30° C.
Inventor(s):	Juan Ignacio Jorquera Nieto, Pere Ristol Debart, Montserrat Costa Rierola
Assignee:	Grifols SA
Application Number:	US12/268,590
Patent Claims:	see list of patent claims

Details for Patent 8,088,416

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Kedrion, S.p.a.	KEDBUMIN	albumin (human)	Injection	125384	June 03, 2011	8,088,416	2028-11-11
Kedrion Biopharma Inc.	KEDBUMIN	albumin (human)	Injection	125384	3-Jun-11	8,088,416	2028-11-11
Kedrion, S.p.a.	KEDBUMIN	albumin (human)	Injection	125384	September 05, 2013	8,088,416	2028-11-11
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 8,088,416

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Country	Patent Number	Estimated Expiration
Argentina	069220	⤷ Start Trial
Australia	2008243225	⤷ Start Trial
Brazil	PI0805167	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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