Last Updated: November 8, 2026

Patent: 8,021,665

Summary for Patent: 8,021,665

Title:	Identification and application of antibiotic synergy
Abstract:	The present invention provides a pharmaceutical composition useful for treating bacterial infections in humans and animals which comprises administering to a human or animal in need thereof, an antibacterially effective combination of a β-lactam antibiotic and an inhibitor of any bacterial peptidoglycan biosynthesis enzyme, especially GlmU, GlmU, MurA, MurB, MurC, MurD, MurE, MurF, MurG, MraY, and UppS. Further provided is a method of discovering synergists for antibiotics including: a) expressing in a cell an antisense nucleic acid against a nucleic acid encoding a gene product so as to reduce the activity or amount of the gene product in the cell, thereby producing a cell sensitized to an antibiotic; b) characterizing the sensitization of the cell to the antibiotic and selecting pairs of antibiotics and genes that result in antibiotic efficacy at one-fifth or less the concentration required in the absence of the antisense gene; c) screening for chemical compounds that inhibit the gene product corresponding to the selected synergistic gene; and d) selecting or creating chemical analogs that inhibit the gene product corresponding to the selected synergistic gene such that the inhibition occurs in the bacteria.
Inventor(s):	Vickie Brown-Driver, Kedar GC, John M. Finn, Robert Haselbeck, Mark Hilgers, Karen Shaw, Mark Stidham
Assignee:	Merck Sharp and Dohme LLC , Trius Therapeutics LLC
Application Number:	US11/636,379
Patent Claims:	see list of patent claims

Details for Patent 8,021,665

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Biogen Inc.	ZINBRYTA	daclizumab	Injection	761029	May 27, 2016	⤷ Start Trial	2026-12-08
Biogen Inc.	ZINBRYTA	daclizumab	Injection	761029	May 26, 2017	⤷ Start Trial	2026-12-08
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 8,021,665

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Country	Patent Number	Estimated Expiration
Japan	2009523120	⤷ Start Trial
United States of America	2007178111	⤷ Start Trial
United States of America	2011294774	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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