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Last Updated: November 28, 2021

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Patent: 7,994,135

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Summary for Patent: 7,994,135
Title:Monomethylvaline compounds capable of conjugation to ligands
Abstract: Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.
Inventor(s): Doronina; Svetlana O. (Snohomish, WA), Senter; Peter D. (Seattle, WA), Toki; Brian E. (Shoreline, WA), Ebens; Allen J. (San Carlos, CA), Kline; Toni Beth (Seattle, WA), Polakis; Paul (Burlingame, CA), Sliwkowski; Mark X. (San Carlos, CA), Spencer; Susan D. (Tiburon, CA)
Assignee: Seattle Genetics, Inc. (Bothell, WA)
Application Number:11/833,954
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 7,994,135
Patent Claims:see list of patent claims

Details for Patent 7,994,135

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 1998-09-25 ⤷  Free Forever Trial 2023-11-06
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 2017-02-10 ⤷  Free Forever Trial 2023-11-06
Genentech, Inc. HERCEPTIN HYLECTA trastuzumab and hyaluronidase-oysk Injection 761106 2019-02-28 ⤷  Free Forever Trial 2023-11-06
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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