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Last Updated: October 26, 2021

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Patent: 7,914,783

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Summary for Patent: 7,914,783
Title:Pharmacological vitreolysis
Abstract: Methods of treating or preventing a disorder, or a complication of a disorder, of an eye of a subject, comprising contacting a vitreous and/or aqueous humor with a composition comprising a truncated form of plasmin comprising a catalytic domain of plasmin (TPCD) are disclosed. TPCDs include, but are not limited to, miniplasmin, microplasmin and derivatives and variants thereof. The methods of the invention can be used to reduce the viscosity of the vitreous, liquefy the vitreous, induce posterior vitreous detachment, reduce hemorrhagic blood from the eye, clear or reduce materials toxic to the eye, clear or reduce intraocular foreign substances from the eye, increase diffusion of a composition administered to an eye, reduce extraretinal neovascularization and any combinations thereof. The method can be used in the absence of, or as an adjunct to, vitrectomy.
Inventor(s): Pakola; Steve (Sleepy Hollow, NY), De Smet; Marc (Amstelveen, NL)
Assignee: ThromboGenics NV (Heverlee, BE)
Application Number:11/786,354
Patent Claims:see list of patent claims

Details for Patent 7,914,783

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Thrombogenics Inc. JETREA ocriplasmin Injection 125422 2017-02-22 ⤷  Free Forever Trial 2022-12-06
Thrombogenics Inc. JETREA ocriplasmin Injection 125422 2012-10-17 ⤷  Free Forever Trial 2022-12-06
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

International Patent Family for US Patent 7,914,783

Country Patent Number Estimated Expiration
South Africa 200505193 ⤷  Free Forever Trial
World Intellectual Property Organization (WIPO) 2004052228 ⤷  Free Forever Trial
United States of America 9770494 ⤷  Free Forever Trial
United States of America 9186394 ⤷  Free Forever Trial
United States of America 8834869 ⤷  Free Forever Trial
United States of America 8747842 ⤷  Free Forever Trial
United States of America 8460655 ⤷  Free Forever Trial
>Country >Patent Number >Estimated Expiration

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