The invention discloses a pharmaceutical composition for treating a subject comprising two or more bioactive nanoparticles, thus treating the subject by co-administering the bioactive nanoparticles to the subject, wherein a first and a second bioactive nanoparticles comprise a shell portion that is dominated by positively charged chitosan, a core portion that contains negatively charged substrate, and at least a first bioactive agent in the first nanoparticle and a second bioactive agent in the second nanoparticle.
Sung; Hsing-Wen (Hsinchu, TW), Tu; Hosheng (Newport Beach, CA)
GP Medical, Inc. (Newport Beach, CA) National Tsing Hua University (Hsinchu, TW)
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