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Last Updated: September 20, 2020

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Patent: 7,858,070

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Summary for Patent: 7,858,070
Title:Multivalent immunoglobulin-based bioactive assemblies
Abstract: The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Preferred embodiments concern hexameric stably tethered structures comprising one or more IgG antibody fragments and which may be monospecific or bispecific. The disclosed methods and compositions provide a facile and general way to obtain stably tethered structures of virtually any functionality and/or binding specificity. The stably tethered structures may be administered to subjects for diagnostic and/or therapeutic use, for example for treatment of cancer or autoimmune disease. The stably tethered structures may bind to and/or be conjugated to a variety of known effectors, such as drugs, enzymes, radionuclides, therapeutic agents and/or diagnostic agents.
Inventor(s): Chang; Chien-Hsing (Downingtown, PA), Goldenberg; David M. (Mendham, NJ), Rossi; Edmund A. (Woodland Park, NJ)
Assignee: IBC Pharmaceuticals, Inc. (Morris Plains, NJ)
Application Number:12/396,605
Patent Claims:see list of patent claims

Details for Patent 7,858,070

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Ferring CHORIONIC GONADOTROPIN gonadotropin, chorionic INJECTABLE;INJECTION 017016 004 1975-06-26   Start Trial IBC Pharmaceuticals, Inc. (Morris Plains, NJ) 2025-10-19 DISCN search
Ferring CHORIONIC GONADOTROPIN gonadotropin, chorionic INJECTABLE;INJECTION 017016 006 1975-06-26   Start Trial IBC Pharmaceuticals, Inc. (Morris Plains, NJ) 2025-10-19 DISCN search
Ferring CHORIONIC GONADOTROPIN gonadotropin, chorionic INJECTABLE;INJECTION 017016 007 1975-06-26   Start Trial IBC Pharmaceuticals, Inc. (Morris Plains, NJ) 2025-10-19 DISCN search
Ferring CHORIONIC GONADOTROPIN gonadotropin, chorionic INJECTABLE;INJECTION 017016 009 1975-06-26   Start Trial IBC Pharmaceuticals, Inc. (Morris Plains, NJ) 2025-10-19 DISCN search
Ferring CHORIONIC GONADOTROPIN gonadotropin, chorionic INJECTABLE;INJECTION 017016 010 1975-06-26   Start Trial IBC Pharmaceuticals, Inc. (Morris Plains, NJ) 2025-10-19 DISCN search
Ferring CHORIONIC GONADOTROPIN gonadotropin, chorionic INJECTABLE;INJECTION 017016 011 1975-06-26   Start Trial IBC Pharmaceuticals, Inc. (Morris Plains, NJ) 2025-10-19 DISCN search
Bel Mar CHORIONIC GONADOTROPIN gonadotropin, chorionic INJECTABLE;INJECTION 017054 001 1974-03-26   Start Trial IBC Pharmaceuticals, Inc. (Morris Plains, NJ) 2025-10-19 DISCN search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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