Last Updated: August 25, 2026

Patent: 7,598,350

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Summary for Patent: 7,598,350

Title:	Human anti-epidermal growth factor receptor antibody
Abstract:	The present invention provides a fully human antibody that binds human EGFR with affinity comparable to or higher than IMC-C225, and that neutralizes activation of EGFR. Antibodies include whole immunoglobulins, monovalent Fabs and single chain antibodies, multivalent single chains antibodies, diabodies, triabodies, and single domain antibodies. The invention further provides nucleic acids and host cells and animals that encode and express these antibodies. The invention further provides a method for neutralizing activation of EGFR, treating in a mammal with neoplastic growth and non-cancerous hyperproliferative diseases using the antibodies alone or in combination with other agents.
Inventor(s):	Meilin Liu, Zhenping Zhu
Assignee:	ImClone LLC
Application Number:	US10/593,804
Patent Claims:	see list of patent claims

Details for Patent 7,598,350

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Eli Lilly And Company	PORTRAZZA	necitumumab	Injection	125547	November 24, 2015	⤷ Start Trial	2025-03-21
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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